Book ChapterDOI
Basic Substance Characteristics and Neuropathological Findings in Drug Abusers
Andreas Büttner
- pp 23-87
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TLDR
In this article, the major psychoactive component, ∆9tetrahydrocannabinol (∆9-THC), interacts with specific CB receptors in the brain.Abstract:
Cannabis is the most frequently abused recreational drug worldwide. Its major psychoactive component, ∆9-tetrahydrocannabinol (∆9-THC), interacts with specific cannabinoid (CB) receptors in the brain. Until today distinct neuropathological alterations have not been described.read more
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Journal ArticleDOI
New psychoactive substances: challenges for drug surveillance, control, and public health responses
Amy Peacock,Amy Peacock,Raimondo Bruno,Raimondo Bruno,Natasa Gisev,Louisa Degenhardt,Wayne Hall,Wayne Hall,Roumen Sedefov,Jason M. White,Kevin V. Thomas,Michael Farrell,Paul Griffiths +12 more
TL;DR: It is proposed that the current means of responding to emerging substances might no longer be fit for purpose in a world in which different substances can be rapidly introduced, and where people who use drugs can change preferences on the basis of market availability.
Journal ArticleDOI
Severe Dopaminergic Neurotoxicity in Primates After a Common Recreational Dose Regimen of MDMA ('Ecstasy')
TL;DR: Nonhuman primates exposed to several sequential doses of MDMA, a regimen modeled after one used by humans, developed severe brain dopaminergic neurotoxicity, in addition to less pronounced serotonergic neurot toxicity, which has implications for mechanisms of MDMA neurotoxicity.
Journal ArticleDOI
Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users
J M Wilson,Allan I. Levey,C Bergeron,Kathryn S. Kalasinsky,Lee Ang,F Peretti,V I Adams,John E. Smialek,W R Anderson,K. Shannak,J Deck,H. B. Niznik,S J Kish +12 more
TL;DR: The data suggest that chronic cocaine use is associated with modestly reduced levels of striatal DA and the DA transporter in some subjects and that these changes might contribute to the neurological and psychiatric effects of the drug.
Journal ArticleDOI
Comparing overdose mortality associated with methadone and buprenorphine treatment
TL;DR: In this short-term study, buprenorphine was associated with lower overdose risk than methadone, and the risk of overdose death per thousand people in treatment was lower for bup Renorphine than for methad one.
Journal ArticleDOI
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms.
Rosario Moratalla,Amit Khairnar,Nicola Simola,Noelia Granado,Jose Ruben Garcia-Montes,Pier Francesca Porceddu,Yousef Tizabi,Giulia Costa,Micaela Morelli +8 more
TL;DR: The species‐specific cellular and molecular mechanisms involved in MDMA and METH‐mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans are summarized.