Book ChapterDOI
Basic Substance Characteristics and Neuropathological Findings in Drug Abusers
Andreas Büttner
- pp 23-87
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TLDR
In this article, the major psychoactive component, ∆9tetrahydrocannabinol (∆9-THC), interacts with specific CB receptors in the brain.Abstract:
Cannabis is the most frequently abused recreational drug worldwide. Its major psychoactive component, ∆9-tetrahydrocannabinol (∆9-THC), interacts with specific cannabinoid (CB) receptors in the brain. Until today distinct neuropathological alterations have not been described.read more
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Journal ArticleDOI
Cocaine increases human immunodeficiency virus type 1 neuroinvasion through remodeling brain microvascular endothelial cells
Milan Fiala,Amy J. Eshleman,John R. Cashman,Justin J. Lin,Albert S. Lossinsky,Vannina Suarez,Wendy Yang,Jun Zhang,Waldemar Popik,Elyse J. Singer,Francesco Chiappelli,Eva Carro,Martin E. Weinand,Marlys H. Witte,James Arthos +14 more
TL;DR: Investigations of the mechanisms by which cocaine increases HIV-1 invasion through brain microvascular endothelial cells (BMVECs) suggest the toxicity of cocaine for the blood-brain barrier may lead to increased virus neuroinvasion and neurovascular complications of cocaine abuse.
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Methamphetamine-induced neurotoxicity: the road to Parkinson’s disease
Bessy Thrash,Kariharan Thiruchelvan,Manuj Ahuja,Vishnu Suppiramaniam,Muralikrishnan Dhanasekaran +4 more
TL;DR: A review of the possible neuroprotective mechanisms of certain drugs against methamphetamine-induced toxicity and how these may aid in understanding the etiology, pathophysiology and progression of the disease process and increase awareness of the risks involved in such drug abuse.
Journal ArticleDOI
Synthetic cannabis and acute ischemic stroke.
TL;DR: Two women aged 22 and 26 were found to have acute, large-territory infarctions of the right middle cerebral artery and the onset of their deficits occurred within hours after first-time exposure to synthetic cannabis.
Journal ArticleDOI
Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation.
TL;DR: It is suggested that coupling of THC to a PTX-sensitive G-protein promotes cytochrome c release, caspase-3 activation and subsequent degeneration of cultured cortical neurones, which may underlie the compromised neuronal function that is associated with marijuana usage.
Journal ArticleDOI
Risk of Cardiovascular Diseases and Stroke Events in Methamphetamine Users: A 10-Year Follow-Up Study.
Ming Chyi Huang,Shu Yu Yang,Shih Ku Lin,Shih Ku Lin,Kuan Yu Chen,Kuan Yu Chen,Ying-Yeh Chen,Chian Jue Kuo,Yen-Ni Hung +8 more
TL;DR: Methamphetamine use is significantly associated with a risk of subsequent cardiovascular and cerebrovascular complications and age appears to be an effect modifier for the risk estimation.