Book ChapterDOI
Basic Substance Characteristics and Neuropathological Findings in Drug Abusers
Andreas Büttner
- pp 23-87
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TLDR
In this article, the major psychoactive component, ∆9tetrahydrocannabinol (∆9-THC), interacts with specific CB receptors in the brain.Abstract:
Cannabis is the most frequently abused recreational drug worldwide. Its major psychoactive component, ∆9-tetrahydrocannabinol (∆9-THC), interacts with specific cannabinoid (CB) receptors in the brain. Until today distinct neuropathological alterations have not been described.read more
References
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Journal ArticleDOI
Cannabis use and psychosis: a review of reviews.
Alkomiet Hasan,Rupert von Keller,Chris Friemel,Wayne Hall,Miriam Schneider,Dagmar Koethe,Dagmar Koethe,F. Markus Leweke,F. Markus Leweke,Wolfgang Strube,Eva Hoch +10 more
TL;DR: A systematic review of meta-analyses and systematic reviews to evaluate the impact of cannabis use on the onset and course of psychoses found that cannabis use is associated with a dose-dependent risk of developing psychotic illness, and cannabis users have an earlier onset of psychotic illness compared to non-users.
Journal ArticleDOI
Neurochemical basis of cannabis addiction
TL;DR: This review describes the experimental methods now available to study the pharmacological responses of cannabinoids related to their addictive effects and how these methods have contributed to advance the knowledge of the specific contribution of different neurochemical systems in cannabis addiction.
Journal ArticleDOI
Increasing potency and price of cannabis in Europe, 2006-16.
Tom P. Freeman,Tom P. Freeman,Teodora Groshkova,Andrew Cunningham,Roumen Sedefov,Paul Griffiths,Michael T. Lynskey +6 more
TL;DR: Marked increases in resin potency and value from 2011 to 2016 are consistent with the emergence of new resin production techniques in European and neighbouring drug markets.
Journal ArticleDOI
Fatal poisoning in drug addicts in the Nordic countries in 2012
K. Wiese Simonsen,H.M.E. Edvardsen,Gunilla Thelander,Ilkka Ojanperä,S. Thordardottir,Ljubica Vukelic Andersen,Pirkko Kriikku,Vigdis Vindenes,Dorte J Christoffersen,G. J. M. Delaveris,G. J. M. Delaveris,Joachim Frost +11 more
TL;DR: The death rates increased in drug addicts in Finland, Iceland and Sweden but decreased in Norway compared to the rates in earlier studies, and the median age of the deceased drug addicts was still highest in Denmark, and deaths of addicts >45 years old increased in all countries.
Journal ArticleDOI
Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers
Michael J. Bannon,Barb Pruetz,Amy B. Manning-Bog,Christopher J. Whitty,Sharon K. Michelhaugh,Paola Sacchetti,James G. Granneman,Deborah C. Mash,Carl J. Schmidt +8 more
TL;DR: It is shown that human NURR1 gene expression is robust within control subjects and reduced markedly within the dopamine neurons of human cocaine abusers, suggesting that NUR1 plays a critical role in vivo in controlling human DAT gene expression and adaptation to repeated exposure to cocaine.