Book ChapterDOI
Basic Substance Characteristics and Neuropathological Findings in Drug Abusers
Andreas Büttner
- pp 23-87
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TLDR
In this article, the major psychoactive component, ∆9tetrahydrocannabinol (∆9-THC), interacts with specific CB receptors in the brain.Abstract:
Cannabis is the most frequently abused recreational drug worldwide. Its major psychoactive component, ∆9-tetrahydrocannabinol (∆9-THC), interacts with specific cannabinoid (CB) receptors in the brain. Until today distinct neuropathological alterations have not been described.read more
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Journal Article
Long-Term Effects of “Ecstasy” Use on Serotonin Transporters of the Brain Investigated by PET
Ralph Buchert,Rainer Thomasius,Bruno Nebeling,Kay Uwe Petersen,Jost Obrocki,Lars Jenicke,Florian Wilke,Lutz Wartberg,P. Zapletalova,Malte Clausen +9 more
TL;DR: The hypothesis of ecstasy-induced protracted alterations of the serotonin transporter (SERT) ligand support the hypothesis of reversibility of the availability of SERT as measured by PET, but this does not imply full reversal of the neurotoxic effects.
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The endocannabinoid system and psychiatric disorders.
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Levamisole: a dangerous new cocaine adulterant.
A Chang,J Osterloh,J Thomas +2 more
TL;DR: Levamisole was a US Food and Drug Administration–approved drug that has been used as an immunomodulator, a chemotherapy adjuvant, and anthelmintic medication, and has high abuse potential because of their amphetamine‐like pharmacological activity.
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Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2013-2016: A Review.
Barry K. Logan,Amanda L A Mohr,Melissa Friscia,Alex J Krotulski,Donna M Papsun,Sherri L. Kacinko,Jeri D. Ropero-Miller,Marilyn A. Huestis +7 more
TL;DR: Recommendations for future toxicological testing of novel psychoactive substances include development and management of a national monitoring program to provide real-time clinical and toxicological data, confirmed analytically, on emerging drugs and their known toxidromes and side effect profiles.
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Neurotoxic amphetamine analogues: effects in monkeys and implications for humans.
George A. Ricaurte,Una D. McCann +1 more
TL;DR: Although findings in animals are compelling, observations in humans are less clear, and it remains to be determined whether amphetamine analogues damage central monoaminergic neurons in humans and, if they do, whether functional consequences ensue.