Journal ArticleDOI
Becoming a new neuron in the adult olfactory bulb
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TLDR
The results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.Abstract:
New neurons are continually recruited throughout adulthood in certain regions of the adult mammalian brain. How these cells mature and integrate into preexisting functional circuits remains unknown. Here we describe the physiological properties of newborn olfactory bulb interneurons at five different stages of their maturation in adult mice. Patch-clamp recordings were obtained from tangentially and radially migrating young neurons and from neurons in three subsequent maturation stages. Tangentially migrating neurons expressed extrasynaptic GABAA receptors and then AMPA receptors, before NMDA receptors appeared in radially migrating neurons. Spontaneous synaptic activity emerged soon after migration was complete, and spiking activity was the last characteristic to be acquired. This delayed excitability is unique to cells born in the adult and may protect circuits from uncontrolled neurotransmitter release and neural network disruption. Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration.read more
Citations
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The glial nature of embryonic and adult neural stem cells
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Adult neurogenesis in the mammalian central nervous system
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Adult neurogenesis and functional plasticity in neuronal circuits
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GABA regulates synaptic integration of newly generated neurons in the adult brain
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Critical period regulation.
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References
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Journal ArticleDOI
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.
TL;DR: It is demonstrated that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus, in amounts similar to enrichment conditions.
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Journal ArticleDOI
Functional neurogenesis in the adult hippocampus
Henriette van Praag,Alejandro F. Schinder,Brian R. Christie,Brian R. Christie,Nicolas Toni,Theo D. Palmer,Theo D. Palmer,Fred H. Gage +7 more
TL;DR: It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
Journal ArticleDOI
Long-distance neuronal migration in the adult mammalian brain
TL;DR: Grafted and endogenous SVZ cells in the lateral ventricle of adult mice migrate long distances and differentiate into neurons in the olfactory bulb.