Journal ArticleDOI
Benzodiazepine receptor recruitment after acute stress in synaptosomal membranes from forebrain of young chicks: action of Triton X-100.
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TLDR
It is suggested that acute stress and Triton X-100 induce receptor recruitment by enhancing [3 H]-flunitrazepam accessibility to a pool of receptors which is unmeasurable either before stress or in absence of detergent.Abstract:
In young chicks submitted to acute stress by forced swimming there was a significant increase in the number of the measurable [3 H]-flunitrazepam receptors in synaptosomal membranes from forebrain. In addition, low sub-solubilizing concentrations of Triton X-100 caused a significant increase in the measurable [3H]-flunitrazepam receptor number in synaptosomal membranes from non-stressed chicks. However, this Triton X-100 stimulatory effect was not observed when tested in synaptosomal membranes from stressed chicks. In all cases the affinity remained unchanged. This result suggest that: (i) acute stress and Triton X-100 induce receptor recruitment by enhancing [3 H]-flunitrazepam accessibility to a pool of receptors which is unmeasurable either before stress or in absence of detergent; (ii) neither recruitment types are additive and they involve receptors coming from the same nonmeasurable pool; (iii) stress induces a maximal recruitment of existing benzodiazepine receptors; (iiii) the pool of nonmeasurable receptors represents about a quarter of the total in control chicks. The recruitment at a short time of stress could be interpreted in terms involving internalization; recycling or modulation of receptors but not its biosynthesis or degradation.read more
Citations
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Enigma of the peripheral benzodiazepine receptor.
Moshe Gavish,Idit Bachman,Rami Shoukrun,Yeshayahu Katz,Leo Veenman,Gary Weisinger,Abraham Weizman +6 more
TL;DR: Benzodiazepines (BZs)2 are used clinically as muscle relaxants, anticonvulsants, anxiolytics, and sedative-hypnotics.
Journal ArticleDOI
Stress and GABA receptors.
TL;DR: For example, this paper found that acute stress induces rapid changes in GABA(A) receptors in experimental animals, with the direction of the changes varying according to the sex of the animals and the stress-paradigm studied.
Journal ArticleDOI
Benzodiazepine receptors increase induced by stress and maze-learning performance in chick forebrain.
Raul Hector Marin,Augusto Arce +1 more
TL;DR: The results suggest that higher performance chicks were more susceptible than lower performance chicks to acute stress associated to increase of both central and peripheral type benzodiazepine receptors, probably due to differences in the degree of endogenous emotionality.
Journal ArticleDOI
Polyamines modulate the binding of GABAA-benzodiazepine receptor ligands in membranes from the rat forebrain.
TL;DR: The present findings indicate that polyamines can modulate the binding characteristics of several different neurotransmitter receptor-ionophore complexes.
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Sex Differences in Central Benzodiazepine Receptor Densities and Circulating Corticosterone Release After Acute Stress in Broiler Chicks
TL;DR: Findings showed sexual differences in acute, stressor-induced benzodiazepine and adrenocortical responses that suggest broiler males are more stress-susceptible than females.
References
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Journal ArticleDOI
Benzodiazepine receptors in rat cerebral cortex and hippocampus undergo rapid and reversible changes after acute stress
TL;DR: The results are discussed in relation to some contradictory findings in the literature and to the fact that the hippocampal formation is related to neural mechanisms underlying behavior and neuroendocrine regulation.
Journal ArticleDOI
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Philippe Soubrie,Marie-Hélène Thiébot,Antoinette Jobert,J.L. Montastruc,Francis Hery,Michel Hamon +5 more
TL;DR: Cold-water stress did not reduce the ability of muscimol and GABA to increase flunitrazepam binding and this post-stress enhancement of benzodiazepine binding was not found to be paralleled by changes in the protective effects of diazepam against picrotoxin- or pentetrazol-induced seizures.
Journal ArticleDOI
Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice.
Lawrence G. Miller,Michael L. Thompson,David J. Greenblatt,Stephen I. Deutsch,Richard I. Shader,Steven M. Paul +5 more
TL;DR: Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro.
Journal ArticleDOI
Benzodiazepine receptors in the brain as affected by different experimental stresses: the changes are small and not undirectional.
TL;DR: The effect of prolonged stress on benzodiazepine receptors is complex and not very pronounced.
Journal Article
Acute, stress-induced changes in the benzodiazepine/gamma-aminobutyric acid receptor complex are confined to the chloride ionophore.
TL;DR: Changes in the chloride ionophore component of the benzodiazepine/gamma-aminobutyric acid receptor complex ("supramolecular complex") were observed in the central nervous system of rats exposed to a brief, ambient temperature swim stress and could represent the physiological attempt of an organism to compensate for stressful changes in the environment.
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