Journal ArticleDOI
Benzpyrene-induced sister chromatid exchanges in lymphocytes of patients with lung cancer.
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TLDR
It is concluded that individual susceptibility to lung cancer cannot be detected by an individual response to benzpyrene, at least in lymphocytes and at the chromosomal level.Abstract:
The effect of benzpyrene on sister chromatid exchange was determined in PHA-stimulated lymphocytes of 18 patients with lung cancer and 11 controls without cancer or bronchopulmonary diseases. Patients and controls did not differ either with respect to the spontaneous rate of sister chromatid exchanges or in their response to the carcinogen. We conclude that individual susceptibility to lung cancer cannot be detected by an individual response to benzpyrene, at least in lymphocytes and at the chromosomal level.read more
Citations
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Journal ArticleDOI
Sister-chromatid exchanges: a report of the GENE-TOX program.
Samuel A. Latt,James W. Allen,Stephen E. Bloom,Anthony V. Carrano,Ernest Falke,David Kram,David Kram,Edward L. Schneider,Rhona Schreck,Raymond R. Tice,Brad Whitfield,Sheldon Wolff +11 more
TL;DR: The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
Book ChapterDOI
Sister Chromatid Exchanges
TL;DR: Analysis of sister chromatid exchange formation in cytological systems has already provided information about chromosome structure and has been used to detect the effects of clastogens and to differentiate between chromosome fragility diseases.
Journal ArticleDOI
Sister chromatid exchanges in the peripheral blood of cigarette smokers and in lung cancer patients; and the effect of chemotherapy
TL;DR: Peripheral blood sister chromatid exchange rates in chronic cigarette smokers and in subjects with cancer do not differ from those in healthy nonsmokers.
Journal ArticleDOI
Increased sister chromatid exchange frequency in lymphocytes in healthy cigarette smokers
TL;DR: It was concluded that cigarette smokers have increased SCE in peripheral lymphocytes, and the influence of cigarette smoking should be considered when using the SCE test principle to evaluate in vivo exposure to potential mutagens.
Journal ArticleDOI
Sister-chromatid exchanges in human lymphocytes exposed during G0 to four classes of DNA-damaging chemicals
TL;DR: The findings suggest that not all classes of clatogenic chemicals which induce SCEs in proliferative cells substituted with BUdR are capable of inducing long-lived lesions in the DNA of Go lymphocytes that can lead to SCE formation.
References
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Journal ArticleDOI
Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
Paul Perry,H. J. Evans +1 more
TL;DR: A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens–carcinogens.
Journal ArticleDOI
Microfluorometric detection of deoxyribonucleic acid replication in human metaphase chromosomes
TL;DR: Growth of cells in medium containing BrdU for two generations allows fluorometric documentation of the semiconservative distribution of newly replicated DNA between sister chromatids, and regions of sister chromated exchange are demarcated.
Journal Article
Isolation of leucocytes from human blood. Further observations. Methylcellulose, dextran, and ficoll as erythrocyteaggregating agents.
Journal ArticleDOI
Aryl hydrocarbon hydroxylase inducibility and bronchogenic carcinoma.
TL;DR: Aryl hydrocarbon hydroxylase is an inducible, membrane-bound enzyme involved in the metabolism of chemical carcinogens and in cultured human lymphocytes there is genetic variation.
Journal ArticleDOI
Familial Aggregation of Lung Cancer in Humans
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Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
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