Bioactive Secondary Metabolites from Fungi of the Genus Cytospora Ehrenb. (Ascomycota)
Boris Y. Kianfé,J. Tchamgoue,Abolfazl Narmani,Rémy Bertrand Teponno,André Ledoux Njouonkou,Marc Stadler,Simeon Fogue Kouam +6 more
TLDR
In this article , a review of the chemical diversity of bioactive secondary metabolites from the genus Cytospora and its potential as an alternative source of secondary metabolites for pharmacological studies is presented.Abstract:
Cytospora is a genus of fungi belonging to the Cytosporaceae family (Sordariomycetes, Ascomycota) considered as a prolific source of specialized metabolites due to their ability to produce diverse secondary metabolites with a broad range of biological activities. Since the first chemical investigation of this genus in the 1980s, further studies have led to the isolation and structural elucidation of several bioactive compounds including cytosporones, nonanolides, macrocyclic dilactones, and terpenoids. This review summarizes, for the first time, the chemical diversity of bioactive secondary metabolites from the genus Cytospora and highlights its potential as an alternative source of secondary metabolites for pharmacological studies. Moreover, this review will serve as a basis for future investigations of compounds of this genus.read more
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Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin.
TL;DR: The total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin are described, characterized by novel molecular architectures at the core, at which lies a more or less complete, cage-like structural motif termed "skyrane".
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A New Tyrosine Kinase Inhibitor from a Marine Isolate of Ulocladium botrytis and New Metabolites from the Marine Fungi Asteromyces cruciatus and Varicosporina ramulosa
TL;DR: The sponge-derived fungi Ulocladium botrytis and Asteromyces cruciatus, and the algal-derived fungus Varicosporina ramulosa, were isolated and extracts from cultures investigated for their metabolite production as discussed by the authors.
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Characterization of polyketide metabolites from foliar endophytes of Picea glauca.
TL;DR: A collection of 250 foliar endophytes of Picea glauca (white spruce) yielded several isolates that produced metabolites toxic to Choristoneura fumiferana, and three of these strains were selected for further study based on their ability to be cultured and produce secondary metabolites under laboratory conditions.
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An Approach to 3,6-Disubstituted 2,5-Dioxybenzoquinones via Two Sequential Suzuki Couplings. Three-Step Synthesis of Leucomelone
TL;DR: Two sequential Suzuki coupling reactions have been developed for efficient synthesis of synthetically and biologically important 3,6-disubstituted 2,5-dioxybenzoquinone architectures in a highly chemoselective controlled manner.
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Bioactive Nonanolide Derivatives Isolated from the Endophytic Fungus Cytospora sp.
Shan Lu,Peng Sun,Tie-Jun Li,Tibor Kurtán,Attila Mándi,Sándor Antus,Karsten Krohn,Siegfried Draeger,Barbara Schulz,Yang-Hua Yi,Ling Li,Wen Zhang +11 more
TL;DR: The discovery of an array of new nonanolides demonstrates the productivity of the fungus, and it is an example of chemical diversity, extending the nonanolide family by derivatives formed by ring cleavage, oxidation, esterification, and Michael addition.