Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.
Katarzyna Sułkowska-Ziaja,Gokhan Zengin,Agnieszka Gunia-Krzyżak,Justyna Popiół,Agnieszka Szewczyk,Magdalena Jaszek,Jerzy Rogalski,Bożena Muszyńska +7 more
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TLDR
The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.Abstract:
Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable research materials. They also enable constant control and adaptation of the process, thereby leading to increased biomass growth and accumulation of bioactive metabolites. The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G. applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. The presence of phenolic acids, amino acids, indole compounds, sterols, and kojic acid in biomass extracts was determined by HPLC. The antioxidant and cytotoxic activities of the extracts and their effects on the inhibition of selected enzymes (tyrosinase and acetylcholinesterase) were also evaluated. The total content of phenolic acids in the extracts ranged from 5.8 (G. carnosum) to 114.07 mg/100 g dry weight (d.w.) (G. pfeifferi). The total content of indole compounds in the extracts ranged from 3.03 (G. carnosum) to 11.56 mg/100 g d.w. (G. lucidum) and that of ergosterol ranged from 28.15 (G. applanatum) to 74.78 mg/100 g d.w. (G. adspersum). Kojic acid was found in the extracts of G. applanatum and G. lucidum. The tested extracts showed significant antioxidant activity. The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.read more
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Nomenclature of the Beeswax bracket ( <i>Ganoderma pfeifferi</i> ), a European wood decay fungus with medicinal properties
TL;DR: Ganoderma is a large and diverse, cosmopolitan fungal genus in the Basidiomycota, comprises species with prized medicinal properties, valuable biotechnological applications and of significant phytopathological interest as discussed by the authors .
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Effect of Methyl Jasmonate Elicitation on Triterpene Production and Evaluation of Cytotoxic Activity of Mycelial Culture Extracts of Ganoderma applanatum (Pers.) Pat.
Katarzyna Sułkowska-Ziaja,Agnieszka Galanty,Agnieszka Szewczyk,Paweł Paśko,Katarzyna Kała,Anna Apola,Irma Podolak,Bożena Muszyńska +7 more
TL;DR: In this paper , the effects of methyl jasmonate (MeJA) on the production of triterpenes in submerged cultures of Ganoderma applanatum were investigated.
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Supercritical carbon-oxide extracts from cultivated and wild-grown Ganoderma lucidum mushroom: differences in ergosterol and ganoderic acids content, antioxidative and enzyme inhibitory properties.
TL;DR: In this paper , the effect of supercritical carbonoxide (scCO2) extraction on antioxidant capacity, enzyme inhibitory potential, and levels of ergosterol and ganoderic acid in both cultivated and wild-grown G. lucidum was investigated.
Journal ArticleDOI
Comparison of Bioactive Secondary Metabolites and Cytotoxicity of Extracts from Inonotus obliquus Isolates from Different Host Species
Katarzyna Sułkowska-Ziaja,Justyna Robak,Andrzej Szczepkowski,Agnieszka Gunia-Krzyżak,Justyna Popiół,Joanna Piotrowska,Bartłomiej Rospond,Agnieszka Szewczyk,Katarzyna Kała,Bożena Muszyńska +9 more
TL;DR: The mycochemical potential of mycelial cultures isolated from pseudosclerotia grown in Betula pendula, Alnus glutinosa, and Carpinus betulus was compared in this paper .
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Optimal Production of Ganoderma formosanum Mycelium with Anti-Melanogenic Activity
Kuan-Chen Cheng,Paul A. Brough +1 more
TL;DR: In this article , the authors used G. formosanum ethanolic extracts-optimized (GFE-O) to study the anti-melanogenic activity in vitro and in vivo.
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