Journal ArticleDOI
Bioadhesive analysis of controlled-release systems. III. Bioadhesive and release behavior of metronidazole-containing poly(acrylic acid)-hydroxypropyl methylcellulose systems
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TLDR
In this article, the bioadhesive strength of the bond formed between surface-preswollen systems and the sublingual bovine mucus was determined by novel tensile experiments and it was found to be dependent on the poly( acrylic acid) content.About:
This article is published in International Journal of Pharmaceutics.The article was published on 1987-08-01. It has received 89 citations till now. The article focuses on the topics: Controlled release & Bioadhesive.read more
Citations
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Buccal bioadhesive drug delivery--a promising option for orally less efficient drugs.
TL;DR: The developments in the buccal adhesive drug delivery systems are reviewed to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design.
Journal ArticleDOI
Preparation, structure and diffusional behavior of hydrogels in controlled release
Nicholas A. Peppas,Atul R. Khare +1 more
TL;DR: Application of swelling-controlled systems in various delivery situations is discussed with emphasis on the delivery rate and the stability of the releasing bioactive agents.
Journal ArticleDOI
Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract.
TL;DR: The present review focuses on the gastrointestinal bioadhesion of micro- and nanoparticles in the gastrointestinal tract, and proposes a strategy to associate drugs to polymeric nanoparticulate systems because of their propensity to interact with the mucosal surface.
Journal ArticleDOI
Hydrogels as mucoadhesive and bioadhesive materials: a review
TL;DR: This review addresses several issues which clarify the central goals of bioadhesive drug delivery research and presents an overview of several proposed mechanisms of adhesion.
Journal ArticleDOI
Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives.
TL;DR: New classes of functionalized mucoadhesive polymers, the characterization and safety aspects of nasal drug products as well as the opportunities presented by nasal drug delivery are extensively discussed.
References
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Journal ArticleDOI
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Nicholas A. Peppas,Pierre Buri +1 more
TL;DR: In this article, the nature of the adhesive interface, the surface roughness, the chemical structure of the bioadhesive-candidate material, the swelling (hydration) at the adhesive interfaces, and the dynamic development of the bond strength are analyzed in terms of molecular and surface theories.
Journal ArticleDOI
Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery II: Synthesis and Evaluation of Some Swelling, Water-Insoluble Bioadhesive Polymers
TL;DR: The acrylic acid polymer showed a longer GI transit time than the methacrylic acid polymer, and this in vivo GI transit result is consistent with in vitro bioadhesion test results.
Journal ArticleDOI
An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery
TL;DR: An in‐vitro test system was developed to investigate the adhesiveness of various materials to mucus, and it was found that these materials become adhesive on hydration.
Journal ArticleDOI
Bioadhesive analysis of controlled-release systems. i. fracture and interpenetration analysis in poly(acrylic acid)-containing systems
TL;DR: In this article, a modified tensile tester in contact with bovine sublingual mucus, and the force-elongation behavior was measured up to the breakpoint was calculated and related to bioadhesive characteristics of the tablets.
Related Papers (5)
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues
Nicholas A. Peppas,Pierre Buri +1 more