Open AccessJournal Article
Analysis of Fickian and non-Fickian drug release from polymers.
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This article is published in Pharmaceutica Acta Helvetiae.The article was published on 1985-01-01 and is currently open access. It has received 2131 citations till now.read more
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Modeling and comparison of dissolution profiles.
TL;DR: Drug dissolution from solid dosage forms has been described by kinetic models in which the dissolved amount of drug (Q) is a function of the test time, t or Q=f(t).
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A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs
TL;DR: In this paper, a simple exponential relation Mt/M∞ = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt is the fractional release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.
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Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).
TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.
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A simple equation for the description of solute release. III. Coupling of diffusion and relaxation
TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.
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Mathematical modeling of drug delivery.
TL;DR: An overview on the current state of the art of mathematical modeling of drug delivery, including empirical/semi-empirical and mechanistic realistic models is given, Analytical as well as numerical solutions are described and various practical examples are given.