Open Access
Biochemistry of oxidative stress
TLDR
The terms "antioxidant", "oxidative stress" and "oxoidative damage" are widely used but rarely defined as discussed by the authors, and a brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.Abstract:
The terms 'antioxidant', 'oxidative stress' and 'oxidative damage' are widely used but rarely defined. This brief review attempts to define them and to examine the ways in which oxidative stress and oxidative damage can affect cell behaviour both in vivo and in cell culture, using cancer as an example.read more
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Journal Article
Free Radicals, Antioxidants in Disease and Health
TL;DR: This mini-review deals with the taxonomy, the mechanisms of formation and catabolism of the free radicals, it examines their beneficial and deleterious effects on cellular activities, and it highlights the potential role of the antioxidants in preventing and repairing damages caused by oxidative stress.
Journal ArticleDOI
Oxidative Stress: Harms and Benefits for Human Health
Gabriele Pizzino,Natasha Irrera,Mariapaola Cucinotta,Giovanni Pallio,Federica Mannino,Vincenzo Arcoraci,Francesco Squadrito,Domenica Altavilla,Alessandra Bitto +8 more
TL;DR: In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
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Oxidative stress: a concept in redox biology and medicine.
TL;DR: “Oxidative stress” as a concept in redox biology and medicine has been formulated in 1985; at the beginning of 2015, approx.
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A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives.
TL;DR: The present review tries to shed some light on research on antioxidants (natural and synthetic) and prooxidants, showing the potential benefits and adverse effects of these opposing events, as well as their mechanisms of action and detection methodologies.
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Melatonin as a natural ally against oxidative stress: a physicochemical examination
TL;DR: In this article, a review summarizes the current progress in understanding the physicochemical insights related to the free radical-scavenging activity of melatonin and concludes that melatonin efficiently protects against oxidative stress by a variety of mechanisms.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
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Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?
Barry Halliwell,Matthew Whiteman +1 more
TL;DR: Methods used to trap RS, including spin trapping and aromatic hydroxylation, are critically examined, with a particular emphasis on those methods applicable to human studies and methods used to detect RS in cell culture.
Journal ArticleDOI
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy,Steven A. McCarroll,Cornelia I. Bargmann,Andrew G. Fraser,Ravi S. Kamath,Julie Ahringer,Hao Li,Cynthia Kenyon +7 more
TL;DR: The findings suggest that the insulin/IGF-I pathway ultimately exerts its effect on lifespan by upregulating a wide variety of genes, including cellular stress-response, antimicrobial and metabolic genes, and by downregulating specific life-shortening genes.
Journal ArticleDOI
Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life
TL;DR: The field of antioxidants and free radicals is often perceived as focusing around the use of antioxidant supplements to prevent human disease, but in fact, antioxidants/free radicals permeate the whole of life, creating the field of redox biology.
Journal Article
Free Radicals, Antioxidants in Disease and Health
TL;DR: This mini-review deals with the taxonomy, the mechanisms of formation and catabolism of the free radicals, it examines their beneficial and deleterious effects on cellular activities, and it highlights the potential role of the antioxidants in preventing and repairing damages caused by oxidative stress.