Journal ArticleDOI
Biological Monitoring of Pesticide Exposure: a review. Introduction.
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This review is based on more than 300 studies published over the period 1980-1999 on biological monitoring of pesticide exposure, and includes measurements of early effects attributable to interaction between the chemical agent and the human body.About:
This article is published in Toxicology.The article was published on 2000-02-07. It has received 300 citations till now. The article focuses on the topics: Exposure assessment & Population.read more
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Genotoxicity of pesticides: a review of human biomonitoring studies
TL;DR: The majority of studies on cytogenetic biomarkers in pesticide-exposed workers have indicated some dose-dependent effects, with increasing duration or intensity of exposure, but data at present on the effect of genetic polymorphism on susceptibility to pesticides does not allow any conclusion.
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Toxic effects of pesticide mixtures at a molecular level: Their relevance to human health
Antonio F. Hernández,Tesifón Parrón,Aristidis Tsatsakis,Mar Requena,Raquel Alarcón,Olga López-Guarnido +5 more
TL;DR: A number of toxicological interactions of pesticide mixtures at a molecular level are addressed, such as those of pesticides acting as endocrine disruptors, the cumulative toxicity of organophosphates and organochlorines resulting in estrogenic effects and the promotion ofOrganophosphate-induced delayed polyneuropathy.
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Acetylcholinesterase as a biomarker in environmental and occupational medicine: new insights and future perspectives.
TL;DR: The aim of this work is to review and discuss the recent findings about acetylcholinesterase, including its sensitivity to other pollutants and the expression of different splice variants, which open new perspective for the future use of this biomarker in environmental and occupational human health monitoring.
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Pesticides exposure in Pakistan: A review
TL;DR: This is the first systematic review of studies done since 1960 to give an integrated picture of pesticides exposure to humans, animals, plants, waters, soils/sediments, atmosphere etc. in Pakistan and will set the future course of action of different studies on pesticide exposure in Pakistan.
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Measurement of Paraoxonase (PON1) Status as a Potential Biomarker of Susceptibility to Organophosphate Toxicity
TL;DR: This work discusses the polymorphisms of paraoxonase (PON1), a liver and serum enzyme that hydrolyzes a number of OP compounds, and its role in modulating the toxicity of OPs, and stresses the importance of determining PON1 status.
References
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A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
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Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome.
TL;DR: Patients appeared to have a distinct clinical entity that developed after the acute cholinergic crisis and before the expected onset of the delayed neuropathy, and this neuromuscular junctional defect may have been the predominant cause of the paralytic symptoms.
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Chlorpyrifos: Pharmacokinetics in human volunteers
TL;DR: Chlorpyrifos and its principal metabolite were rapidly eliminated and therefore have a low potential to accumulate in man on repeated exposures and therefore could be used to quantify the amount of chlorpyrIFos absorbed under actual use conditions.
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Percutaneous penetration of some pesticides and herbicides in man
TL;DR: Twelve radiolabeled 14C-pesticides and herbicides were applied to the forearms of human subjects, and the urinary excretion of 14C was quantitated, indicating that all the pesticides and herbicide tested are absorbed.
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Paraquat poisoning: significance of plasma-paraquat concentrations
TL;DR: It is suggested that measurement of plasma-paraquat concentrations is useful in assessing the severity and predicting the outcome of poisoning.