Journal ArticleDOI
Biologically active androgens and œstradiol in men with chronic liver disease
TLDR
The combination of normal unbound-plasma- œstradiol and reduced unbound androgen levels of hypo- gonadism in chronic liver disease and increased hepatic S.B.H.G. production is suggested.About:
This article is published in The Lancet.The article was published on 1973-01-27. It has received 144 citations till now. The article focuses on the topics: Chronic liver disease & Liver disease.read more
Citations
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Journal ArticleDOI
Sex-hormone-binding globulin.
TL;DR: By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed, and the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.
Journal ArticleDOI
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
TL;DR: It is shown that alcohol markedly affects testosterone metabolism independently of cirrhosis or nutritional factors and increased the metabolic clearance rate of testosterone in most subjects studied.
Journal ArticleDOI
Hypogonadism in alcoholic liver disease: evidence for a double defect.
David H. Van Thiel,David H. Van Thiel,Roger Lester,Roger Lester,Richard J. Sherins,Richard J. Sherins +5 more
TL;DR: No correlation between any specific biochemical assessment of the severity of liver disease and the degree of hormonal derangement was observed, but mean plasma testosterone levels were lower than normal.
Journal ArticleDOI
Changes in the pituitary-testicular system with age.
H. W. G. Baker,H. G. Burger,D. M. De Kretser,B. Hudson,S. O'connor,Christina Wang,A. Mirovics,J. Court,M. Dunlop,G. C. Rennie +9 more
TL;DR: The evidence is consistent with a primary decrease in testicular function over the age of 40 years, and the metabolic clearance rates (MCR) of testosterone and oestradiol also fell in old age, while the conversion of testosterone to ostradiol was increased.
Journal ArticleDOI
Alcohol-induced testicular atrophy. An experimental model for hypogonadism occurring in chronic alcoholic men.
David H. Van Thiel,David H. Van Thiel,Judith S. Gavaler,Judith S. Gavaler,Roger Lester,Roger Lester,M. David Goodman,M. David Goodman +7 more
TL;DR: In this article, an animal model was developed to examine perturbation in gonadal function that occurs in man as a consequence of chronic ethanol ingestion and confirms previous data which suggest that ethanol is a primary testicular toxin.
References
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Testosterone secretion and metabolism in male senescence
TL;DR: It was observed that plasma testosterone levels and the apparent free plasma testosterone concentration remain within the same range from adolescence until the age of 50 yr, but that from the 6th decade on, the mean plasma levels decrease rather rapidly, with a wide range of individual values.
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Capacity of the Testosterone-Binding Globulin in Human Plasma and Influence of Specific Binding of Testosterone on Its Metabolic Clearance Rate
TL;DR: The binding capacity (TeBC) and binding index (BI) of the testosterone binding globulin (TeBG) have been studied in several groups of patients as discussed by the authors, including male hypogonadism in hyperthyroidism, and in males with chronic asthmatic bronchitis or cirrhosis of the liver.
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A Simplified Method for the Quantitative Determination of Testosterone-Estradiol-Binding Globulin Activity in Human Plasma
TL;DR: A rapid and simple method for the measurement of testosterone-estradiol-binding globulin in human plasma is described, and normal values were observed in abstinent alcoholics and in pregnant subjects with diabetes or hypertension.
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Sex-Hormone-Binding Globulin is an Oestrogen Amplifier
C W Burke,D C Anderson +1 more
TL;DR: A novel biological role for a specific plasma-binding protein in the regulation of oestrogen and androgen activity in man is suggested.
Journal ArticleDOI
Inactivity in vivo of transcortin-bound cortisol.
TL;DR: By means of a liver glycogen maintenance assay for corticosteroids, it was shown that transcortin-bound cortisol is biologically inactive.