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Biphasic Creep and Stress-Relaxation of Articular-Cartilage in Compression - Theory and Experiments

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This article is published in Journal of Biomechanical Engineering-transactions of The Asme.The article was published on 1980-02-01. It has received 2376 citations till now. The article focuses on the topics: Stress relaxation & Creep.

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Basic science of articular cartilage repair.

TL;DR: A multidisciplinary approach, combining clinical experience, cogent biomaterial designs, new cell biologic processes, biomechanical assessment, and modern molecular biology, clearly is leading toward clinically acceptable, viable, and consistent articular cartilage regeneration.
Journal ArticleDOI

Confined and unconfined stress relaxation of cartilage: appropriateness of a transversely isotropic analysis.

TL;DR: It is suggested that the linear transversely isotropic biphasic model could not simultaneously describe the observed stress relaxation and equilibrium behavior of calf cartilage.
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An analysis of the effects of depth-dependent aggregate modulus on articular cartilage stress-relaxation behavior in compression.

TL;DR: The calculations show that the mechanical environment inside an inhomogeneous tissue differs significantly from that inside a homogeneous tissue, and indicate that the need to incorporate an inhmogeneous aggregate modulus, or an anisotropy, into the biphasic theory to describe articular cartilage depends largely on the motivation for the study.
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Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs.

TL;DR: It is shown for the first time that an injection of the growth factor, OP-1, restored the biomechanical properties of IVDs in a rabbit model of IVD degeneration.
Journal ArticleDOI

Cartilage injury by ramp compression near the gel diffusion rate.

TL;DR: The gel diffusion rate represented a threshold separating different biomechanical regimes of injury, but at which cartilage was relatively “safe” from injury.
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