Journal ArticleDOI
Biphasic Creep and Stress-Relaxation of Articular-Cartilage in Compression - Theory and Experiments
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This article is published in Journal of Biomechanical Engineering-transactions of The Asme.The article was published on 1980-02-01. It has received 2376 citations till now. The article focuses on the topics: Stress relaxation & Creep.read more
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Journal ArticleDOI
Tissue-engineered cartilage with inducible and tunable immunomodulatory properties
Katherine A. Glass,Jarrett M. Link,Jonathan M. Brunger,Franklin T. Moutos,Charles A. Gersbach,Farshid Guilak +5 more
TL;DR: Functional engineered cartilage with immunomodulatory properties that allow chondrogenesis in the presence of pathologic levels of IL-1 by inducing overexpression ofIL-1 receptor antagonist in MSCs via scaffold-mediated lentiviral gene delivery are developed.
Journal ArticleDOI
The Effect of Sustained Compression on Oxygen Metabolic Transport in the Intervertebral Disc Decreases with Degenerative Changes
TL;DR: Results indicate that external loads influence the oxygen and lactate regional distributions within the disc when large volume changes modify diffusion distances and diffusivities, and suggest that healthy disc properties have a positive effect of loading on metabolic transport.
Journal ArticleDOI
Inverse analysis of constitutive models: biological soft tissues.
Fulin Lei,Andras Z. Szeri +1 more
TL;DR: Though the optimization procedure is illustrated here for unconfined compression only, it can be adapted easily to other experimental configurations such as confined compression, indentation and tensile test, and can be applied in other areas of biomechanics where material parameters need to be extracted from experimental data.
Journal ArticleDOI
Influence of stress rate on water loss, matrix deformation and chondrocyte viability in impacted articular cartilage
TL;DR: The mechano-biological response of articular cartilage depended on magnitude and rate of impact loading, and the significance of the inhomogeneous structure and composition of the cartilage matrix was accentuated when explants impacting on the deep zone had less water loss and matrix deformation, higher DIM, and no cell death compared to explants impacted on the articular surface.
Journal ArticleDOI
Elastic anisotropy of articular cartilage is associated with the microstructures of collagen fibers and chondrocytes
John Z. Wu,Walter Herzog +1 more
TL;DR: The analysis suggests that the combination of proteoglycan matrix, fiber orientation, and shape of chondrocytes are intimately related and are likely adapted to optimize the mechanical stability and load carrying capacity of the structure.
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