Journal ArticleDOI
Bone substitutes: an update.
TLDR
An overview of bone grafts and graft substitutes available for clinical applications is presented and osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold are provided.Abstract:Â
Autograft is considered ideal for grafting procedures, providing osteoinductive growth factors, osteogenic cells, and an osteoconductive scaffold. Limitations, however, exist regarding donor site morbidity and graft availability. Allograft on the other hand, posses the risk of disease transmission. Synthetic graft substitutes lack osteoinductive or osteogenic properties. Composite grafts combine scaffolding properties with biological elements to stimulate cell proliferation and differentiation and eventually osteogenesis. We present here an overview of bone grafts and graft substitutes available for clinical applications.read more
Citations
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Bone Tissue Engineering: Recent Advances and Challenges
TL;DR: The fundamentals of bone tissue engineering are discussed, highlighting the current state of this field, and the recent advances of biomaterial and cell-based research, as well as approaches used to enhance bone regeneration.
Journal ArticleDOI
Bone regeneration: current concepts and future directions
TL;DR: Improved 'local' strategies in terms of tissue engineering and gene therapy, or even 'systemic' enhancement of bone repair, are under intense investigation, in an effort to overcome the limitations of the current methods, to produce bone-graft substitutes with biomechanical properties that are as identical to normal bone as possible.
Journal ArticleDOI
Bioceramics of calcium orthophosphates
TL;DR: Current biomedical applications of calcium orthophosphate bioceramics include replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmentation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery.
Journal ArticleDOI
Injectable hydrogels for cartilage and bone tissue engineering.
Mei Liu,Xin Zeng,Chao Ma,Huan Yi,Zeeshan Ali,Zeeshan Ali,Xianbo Mou,Song Li,Yan Deng,Yan Deng,Nongyue He,Nongyue He +11 more
TL;DR: The selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering are described and the biology of Cartilage and the bony ECM is summarized.
Journal ArticleDOI
Chitosan composites for bone tissue engineering--an overview.
TL;DR: The preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed.
References
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Journal ArticleDOI
Morbidity at bone graft donor sites.
TL;DR: A review of the medical records of 239 patients with 243 autogenous bone grafts was undertaken to document the morbidity at the donor sites, finding that there was a much higher complication rate if the incision used for the surgery was also the sameincision used to harvest the bone graft.
Journal ArticleDOI
Complications of Iliac Crest Bone Graft Harvesting
TL;DR: In a retrospective review of 414 consecutive cases of iliac crest bone graft procedures performed at Brooke Army Medical Center from 1983 to 1993, 41 (10%) minor and 24 (5.8%) major complications were identified.
Journal ArticleDOI
Iliac crest bone graft harvest donor site morbidity. A statistical evaluation.
Banwart Jc,Asher Ma,Hassanein Rs +2 more
TL;DR: This study analyzed the cause, rate, and risk factors of iliac crest bone graft donor site morbidity to develop strategies of prevention of complications or problems.
Journal ArticleDOI
Bone graft and bone graft substitutes: a review of current technology and applications.
TL;DR: A variety of bone graft and bone graft substitute materials are discussed, among the osteoconductive materials outlined are the hydroxyapatite and tricalcium phosphate ceramics and some reportedly osteoactive polymers.
Journal ArticleDOI
The effect of implants loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects
TL;DR: Autologous cultured bone-marrow-derived mesenchymal stem cells that had been loaded onto porous ceramic cylinders elicited the healing of critical-sized segmental bone defects in dogs, suggesting that this approach may provide an alternative to autologous bone-grafting.