Bovine leukemia virus: an exogenous RNA oncogenic virus
Richard Kettmann,Daniel Portetelle,Marc Mammerickx,Yvette Cleuter,Daniel Dekegel,Michel M. Galoux,Jacques Ghysdael,Arsène Burny,Hubert Chantrenne +8 more
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TLDR
Molecular hybridizations between BLV/[3H]cDNA and several viral RNAs show that BLV is not related to Mason-Pfizer monkey virus, simian sarcoma associated virus, feline leukemia virus, or avian myeloblastosis virus.Abstract:
Short-term cultures of bovine leukemic lymphocytes release virus particles with biochemical properties of RNA oncogenic viruses. These particles, tentatively called bovine leukemia virus (BLV), have a high molecular weight RNA-reverse transcriptase complex and a density of 1.155 g/ml in sucrose solutions. Molecular hybridizations between BLV/[3H]cDNA and several viral RNAs show that BLV is not related to Mason-Pfizer monkey virus, simian sarcoma associated virus, feline leukemia virus, or avian myeloblastosis virus. These results were confirmed by hybridization between BLV 70S RNA and [3H]cDNA synthesized in the various viruses tested. The high preference of BLV reverse transciptase for Mg++ as the divalent cation suggests that BLV might be an atypical mammalian leukemogenic "type C" virus. DNA-DNA hybridization studies using BLV [3H]cDNA as a probe strongly suggest that the DNA of bovine leukemic cells contains viral sequences that cannot be detected in normal bovine DNA.read more
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Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human
Nicolas Gillet,Arnaud-Francois Florins,Mathieu Boxus,Catherine Burteau,Annamaria Nigro,Fabian Vandermeers,Herve Balon,Amel Bouzar,Julien Defoiche,Arsène Burny,Michal Reichert,Richard Kettmann,Luc Willems +12 more
TL;DR: This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis and cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far.
Bovine Leukemia Virus
Richard Kettmann,Arsène Burny,Isabelle Callebaut,Louis Droogmans,M. Mammerickx,Luc Willems,Daniel Portetelle +6 more
TL;DR: The most common neoplasm of the bovine species is, by far, lymphoid leukosis, which is a chronic disease, evolving over extended periods (1–8 years), with tumors developing in only a small number of infected animals.
Journal Article
Pathobiology of bovine leukemia virus
I Schwartz,D Lévy +1 more
TL;DR: Bovine leukemia virus infection remains endemic in many countries including the United States and prophylactic strategies involving recombinant vaccine vectors, genetically modified BLV and transgenic animals resistant to the infection are under study.
Journal ArticleDOI
Preventive and therapeutic strategies for bovine leukemia virus: lessons for HTLV.
Sabrina Rodriguez,Arnaud-Francois Florins,Nicolas Gillet,Alix de Brogniez,Maria-Thérésa Sanchez-Alcaraz,Mathieu Boxus,Fanny Boulanger,Gerónimo Gutiérrez,Karina Trono,Irene Alvarez,Lucas Vagnoni,Luc Willems +11 more
TL;DR: This review summarizes the different attempts previously developed to decrease seroprevalence of BLV and proposes a new approach based on competitive infection with virus deletants aiming at reducing proviral loads.
Book ChapterDOI
Bovine Leukemia Virus
Richard Kettmann,Arsène Burny,Isabelle Callebaut,Louis Droogmans,M. Mammerickx,Luc Willems,Daniel Portetelle +6 more
TL;DR: The first attempt to study bovine leukosis (BL) and characterize it as a clinical entity was made by Siedam-grotzky et al. as discussed by the authors.
References
More filters
Journal ArticleDOI
Repeated Sequences in DNA
Roy J. Britten,D. E. Kohne +1 more
TL;DR: Hundreds of thousands of copies of DNA sequences have been incorporated into the genomes of higher organisms and used in medicine, science, and engineering.
Journal ArticleDOI
Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses
TL;DR: Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template, apparently the classical process of information transfer from DNA to RNA can be inverted.
Journal ArticleDOI
RNA-dependent DNA polymerase in virions of Rous sarcoma virus.
Howard M. Temin,Satoshi Mizutani +1 more
TL;DR: Viral RNA-dependent DNA Polymerase: RNA- dependent DNA polymerase in Virions of Rous Sarcoma Virus and its role in cell reprograming is studied.
Journal ArticleDOI
Purification and further properties of single-strand-specific nuclease from Aspergillus oryzae.
TL;DR: The utility of this nuclease for measuring annealing of labeled DNA is discussed and the enzyme is shown to be absolutely specific for single-stranded nucleic acids.