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Journal ArticleDOI

Brain correlates of craving for online gaming under cue exposure in subjects with Internet gaming addiction and in remitted subjects

TLDR
Brain correlates of cue‐induced craving to play online games in subjects with Internet gaming addiction, subjects in remission from IGA and controls showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulates were activated in response to gaming cues and their activation was stronger in the IGA group than those in the control group.
Abstract
This study aimed to evaluate brain correlates of cue-induced craving to play online games in subjects with Internet gaming addiction (IGA), subjects in remission from IGA and controls. The craving response was assessed by event-related design of functional magnetic resonance images (fMRIs). Fifteen subjects with IGA, 15 in remission from IGA and 15 controls were recruited in this study. The subjects were arranged to view the gaming screenshots and neutral images under investigation of fMRIs. The results showed that bilateral dorsolateral prefrontal cortex (DLPFC), precuneus, left parahippocampus, posterior cingulate and right anterior cingulate were activated in response to gaming cues in the IGA group and their activation was stronger in the IGA group than those in the control group. Their region-of-interest was also positively correlated with subjective gaming urge under cue exposure. These activated brain areas represent the brain circuit corresponding to the mechanism of substance use disorder. Thus, it would suggest that the mechanism of IGA is similar to substance use disorder. Furthermore, the IGA group had stronger activation over right DLPFC and left parahippocampus than did the remission group. The two areas would be candidate markers for current addiction to online gaming and should be investigated in future studies.

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Citations
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Internet gaming disorder and the DSM‐5

TL;DR: An editorial reviews the DSM process and rationale for inclusion of internet gaming disorder, and it suggests directions for much needed research in this area.
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Internet addiction and problematic Internet use: A systematic review of clinical research.

TL;DR: A consensus regarding diagnostic criteria and measures is needed to improve reliability across studies and to develop effective and efficient treatment approaches for treatment seekers.
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Prefrontal control and Internet addiction: a theoretical model and review of neuropsychological and neuroimaging findings

TL;DR: Results from functional neuroimaging and other neuropsychological studies demonstrate that cue-reactivity, craving, and decision making are important concepts for understanding Internet addiction.
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Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint?

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Journal ArticleDOI

Brain substrates of craving to alcohol cues in subjects with alcohol use disorder

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