Journal ArticleDOI
C–halogen···π interactions and their influence on molecular conformation and crystal packing: a database study
M.D. Prasanna,T. N. Guru Row +1 more
TLDR
In this paper, the role of C−X−π interactions in conformational and crystal engineering control in organic crystal structures was investigated. But the results showed that organic fluorine has a greater propensity for the formation of such interactions rather than accepting hydrogen bonds.About:
This article is published in Crystal Engineering.The article was published on 2000-06-01. It has received 183 citations till now. The article focuses on the topics: Crystal engineering & Crystal.read more
Citations
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A Medicinal Chemist’s Guide to Molecular Interactions
TL;DR: This article compile and review the literature on molecular interactions as it pertains to medicinal chemistry through a combination of careful statistical analysis of the large body of publicly available X-ray structure data and experimental and theoretical studies of specific model systems.
Journal ArticleDOI
Fluorine in crystal engineering—“the little atom that could”
TL;DR: This review provides knowledge on fluorine interactions classified into phenyl-perfluorophenyl-, C-FH, FF and C-FpiF interactions.
Journal ArticleDOI
The Bright Future of Unconventional σ/π-Hole Interactions
TL;DR: The physical nature of σ- and π-hole interactions is described, a selection of inquiries that utilise ρ- andπ-holes are presented, and an overview of analyses of structural databases (CSD/PDB) that demonstrate how prevalent these interactions already are in solid-state structures are given.
Journal ArticleDOI
Halogen bonding (X‐bonding): A biological perspective
TL;DR: A broad overview of X‐bonds is presented from the perspective of a biologist who may not be familiar with this recently rediscovered class of interactions and may be interested in how they can be applied as a highly directional and specific component of the molecular toolbox.
Journal ArticleDOI
Recent advances in the development of aryl-based foldamers.
Ishu Saraogi,Andrew D. Hamilton +1 more
TL;DR: This critical review of the developments in aromatic foldamers in the last two years will be of interest to people working on the structural and functional mimicry of biomolecules and will stimulate further research into novel applications.
References
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Journal ArticleDOI
The development of versions 3 and 4 of the Cambridge Structural Database System
F.H. Allen,John E. Davies,Jean J. Galloy,Owen Johnson,Olga Kennard,Clare F. Macrae,Eleanor M. Mitchell,Gary F. Mitchell,J. Michael Smith,David G. Watson +9 more
TL;DR: The CSD itself acts as a computerized depository for large-volume numerical results for some 30 journals and may conveniently be categorized according to its "dimensionality", as described below and illustrated in Figure 1.
Journal ArticleDOI
The C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it?
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Organic Fluorine Hardly Ever Accepts Hydrogen Bonds
Jack D. Dunitz,Robin Taylor +1 more
TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.
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C−H···F Interactions in the Crystal Structures of Some Fluorobenzenes
Venkat R. Thalladi,Hans-Christoph Weiss,Dieter Bläser,Roland Boese,Ashwini Nangia,Gautam R. Desiraju +5 more
TL;DR: The existence and nature of C−H···F−C interactions in crystalline fluorobenzenes 1−3 and 7−10 are discussed in this paper, where the authors compare the C−F−O/C−H−N interactions in these four crystal structures.
Journal ArticleDOI
How good is fluorine as a hydrogen bond acceptor
TL;DR: In this article, a review of short F…H contacts from all of the organofluorine compounds deposited in the Cambridge Structural Database System (CSDS) was carried out and in parallel a theoretical estimate of the energy of such contacts with inter nuclear distance was executed.