Journal ArticleDOI
Calcitonin gene related peptide released from dural nerve fibers mediates increase of meningeal blood flow in the rat
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TLDR
The parietal dura mater encephali of the rat was shown by immunohistochemistry to be densely innervated by calcitonin gene related peptide (CGRP) immunoreactive nerve fibers spreading around the me...Citations
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Journal ArticleDOI
Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
Jochen K. Lennerz,Victor Rühle,Eugene P. Ceppa,Eugene P. Ceppa,Winfried Neuhuber,Nigel W. Bunnett,Eileen F. Grady,Karl Messlinger +7 more
TL;DR: It is concluded that CGRP receptors are associated with structural targets of known C GRP effects (vasodilation, mast cell degranulation) and targets of unknown function (Schwann cells) in the trigeminovascular system.
Journal ArticleDOI
Sensory neuropeptides: their role in inflammation and wound healing
TL;DR: Evidence that the neuropeptides substance P and CGRP, acting via tachykinin NK1 and NK2 receptors, play a pro-inflammatory role in disease and a beneficial role in wound healing are concentrated on.
Book ChapterDOI
Trigeminal sensory system.
Phil M.E. Waite,Ken W.S. Ashwell +1 more
TL;DR: The unique anatomy of the pathway for facial sensations, involving the trigeminal ganglion and its associated nuclei within the brainstem, and the opportunities that this offers for training and rehabilitation are addressed.
Journal ArticleDOI
Neurogenic inflammation and its role in migraine.
TL;DR: Target analysis of factors have opened up the possibilities of a dialogue between the neurons and immune cells in driving such a sterile neuroinflammatory state in migraine pathophysiology.
Journal ArticleDOI
The Nonpeptide Calcitonin Gene-Related Peptide Receptor Antagonist BIBN4096BS Lowers the Activity of Neurons with Meningeal Input in the Rat Spinal Trigeminal Nucleus
TL;DR: It is concluded that the endogenous release of CGRP significantly contributes to the maintenance of spontaneous activity in STN neurons and may offer a new therapeutic strategy for the treatment of facial pain and primary headaches.
References
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Journal ArticleDOI
Calcitonin gene-related peptide is a potent vasodilator
TL;DR: It is suggested that local extravascular release of CGRP may be involved in the physiological control of blood flow and that circulating C GRP may contribute to hyperaemia in certain pathological conditions.
Journal ArticleDOI
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
TL;DR: A substantial elevation of the calcitonin gene‐related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine, and may have importance in the pathophysiology of migraine.
Journal ArticleDOI
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation
Fred Lembeck,Peter Holzer +1 more
TL;DR: It is concluded that vasodilation and plasma extravasation following antidromic stimulation of sensory nerves are initiated by peripheral release of substance P from chemosensitive pain fibres.
Journal ArticleDOI
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin
Journal ArticleDOI
The neurobiology of vascular head pain.
TL;DR: The relationship of trigeminovascular fibers to the pathogenesis of vascular head pain sheds light on possible mechanisms of migraine and other central nervous system conditions associated with headache and inflammation.
Related Papers (5)
Vasoactive peptide release in the extracerebral circulation of humans during migraine headache
The trigeminovascular system and migraine: Studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats
Peter J. Goadsby,Lars Edvinsson +1 more