Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth
George D. Kamphaus,Pablo C. Colorado,David J. Panka,Helmut Hopfer,Ramani Ramchandran,Adriana Torre,Yohei Maeshima,James W. Mier,Vikas P. Sukhatme,Raghu Kalluri +9 more
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TLDR
Canstatin is a powerful therapeutic molecule for suppressing angiogenesis and tumor growth and it is demonstrated that apoptosis induced by canstatin was associated with a down-regulation of the anti-apoptotic protein, FLIP.About:
This article is published in Journal of Biological Chemistry.The article was published on 2000-01-14 and is currently open access. It has received 448 citations till now. The article focuses on the topics: Tumstatin & Angiogenesis.read more
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Tumorigenesis and the angiogenic switch
TL;DR: A more detailed understanding of the complex parameters that govern the interactions between the tumour and vascular compartments will help to improve anti-angiogenic strategies — not only for cancer treatment, but also for preventing recurrence.
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Basement membranes: structure, assembly and role in tumour angiogenesis
TL;DR: The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.
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Clinical translation of angiogenesis inhibitors.
Robert S. Kerbel,Judah Folkman +1 more
TL;DR: Angiogenesis inhibitors are a new class of drugs, for which the general rules involving conventional chemotherapy might not apply, and clinical application depends partly on the transfer of expertise from scientists who are familiar with the biology of angiogenesis to clinicians.
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Regulation of matrix biology by matrix metalloproteinases
Joni D. Mott,Zena Werb +1 more
TL;DR: It is now clear that MMP activity is much more directed and causes the release of cryptic information from the ECM, and MMPs have become a focal point for understanding matrix biology.
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Tumor stroma and regulation of cancer development.
Thea D. Tlsty,Lisa M. Coussens +1 more
TL;DR: This review highlights the aspects of cancer development that, like organogenesis during embryonic development and tissue repair in adult mammals, are regulated by interactions between epithelial cells, activated stromal cells, and soluble and insoluble components of the extracellular matrix.
References
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Angiogenesis in cancer, vascular, rheumatoid and other disease
TL;DR: Think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth, which may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.
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Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.
Michael S. O'Reilly,Thomas Boehm,Yuen Shing,Naomi Fukai,George Vasios,William S. Lane,Evelyn Flynn,James R Birkhead,Bjorn R. Olsen,Judah Folkman +9 more
TL;DR: This work has identified endostatin, an angiogenesis inhibitor produced by hemangioendothelioma, a 20 kDa C-terminal fragment of collagen XVIII that specifically inhibits endothelial proliferation and potently inhibitsAngiogenesis and tumor growth.
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Requirement of vascular integrin alpha v beta 3 for angiogenesis
TL;DR: The adhesion receptor integrin alpha v beta 3 was identified as a marker of angiogenic vascular tissue in this paper, and it showed a fourfold increase in expression during angiogenesis on the chick chorioallantoic membrane.
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COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy
TL;DR: The collagen superfamily of proteins now contains at least 19 proteins formally defined as collagens and an additional ten proteins that have collagen-like domains, and a number of experiments suggest it may be possible to inhibit collagen synthesis with oligo-nucleotides or antisense genes.