Journal ArticleDOI
Carboxypeptidase in blood and other fluids—I.: Properties, distribution, and partial purification of the enzyme
TLDR
The carboxypeptidase exists in the blood sera of mammals, birds, amphibia, and other animals, in lymph, and in human urine and thrombocytes, but not in erythrocytes, and the possible existence of several carboxypesptidases in blood is discussed.About:
This article is published in Biochemical Pharmacology.The article was published on 1964-06-01. It has received 95 citations till now. The article focuses on the topics: Carboxypeptidase & Lysine carboxypeptidase.read more
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Book ChapterDOI
Anaphylatoxins: C3a and C5a.
TL;DR: This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation that elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic reactions.
Journal ArticleDOI
Fate of Angiotensin I in the Circulation
K. K. F. Ng,John R. Vane +1 more
TL;DR: The results of the blood-bathed organ technique do not support hypotheses which suggest a completely intra-renal role for the renin–angiotensin system.
Journal ArticleDOI
Purification and characterization of enkephalin convertase, an enkephalin-synthesizing carboxypeptidase.
TL;DR: Purified enkephalin convertase appears homogeneous on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, showing a single band with an apparent molecular weight of 50,000 for enzyme isolated from all three tissues, suggesting that enkephal convertase activity represents the same enzyme in adrenal medulla, brain, and pituitary.
Journal ArticleDOI
The renal kallikrein-kinin system.
TL;DR: Although the functions of the kallikrein-kinin system are incompletely defined, there is evidence that it may regulate renal blood flow, modulate tubular salt and water transport, and participate in the pathogenesis of a number of human diseases, such as hypertension.
Journal ArticleDOI
Second kininase in human blood plasma.
H. Y. T. Yang,E. G. Erdös +1 more
TL;DR: COHN fraction IV-1 of human plasma contains an enzyme, carboxypeptidase N, which inactivates bradykinin and kallidin1,2 and also cleaves smaller substrates such as hippuryl-L-lysine (HLL)3.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
Journal ArticleDOI
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds
Stanford Moore,William H. Stein +1 more
TL;DR: A modified ninhydrin reagent for the photometric determination of amino acids and related compounds and its application in drug discovery is described.
Journal ArticleDOI
Peptide Separation by Two-dimensional Chromatography and Electrophoresis
TL;DR: The separation of peptides from controlled proteolytic digests by two-dimensional paper chromatography and electrophoresis is finding wide application to studies of protein structure.
Related Papers (5)
An enzyme in human blood plasma that inactivates bradykinin and kallidins
Ervin G. Erdös,Eleanor M. Sloane +1 more