Journal ArticleDOI
Catalponol enhances dopamine biosynthesis and protects against L-DOPA-induced cytotoxicity in PC12 cells.
Hai-Shan Huang,Xiang-Hua Han,Bang-Yeon Hwang,Jae-In Park,Se-Kuel Yoo,Hyun-Sook Choi,Sung-Cil Lim,Myung Koo Lee +7 more
TLDR
Results suggest that 1 enhanced dopamine biosynthesis by inducing TH activity and protected against l-DOPA-induced cytotoxicity in PC12 cells, which was mediated by the increased levels of cyclic AMP.About:
This article is published in Journal of Asian Natural Products Research.The article was published on 2009-09-15. It has received 3 citations till now. The article focuses on the topics: Tyrosine hydroxylase & Dopamine.read more
Citations
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Efficient Enantioselective Syntheses of Sertraline, 2‐Epicatalponol and Catalponol from Tetralin‐1,4‐dione
TL;DR: In this article, tetralin-1,4-dione was reduced with catecholborane in the presence of 3,3-diphenyl-1-butyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole as catalyst to give enantiomerically highly enriched 4-hydroxynaphthalene in an efficient one-pot procedure.
Journal ArticleDOI
Modulatory effects of sesamin on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells.
TL;DR: Results suggested that sesamin enhanced dopamine biosynthesis and L-DOPA-induced increase in dopamine levels by inducing TH activity and TH gene expression, which was mediated by cAMP-PKA-CREB systems, and might serve as an adjuvant phytonutrient for neurodegenerative diseases.
Journal ArticleDOI
One-Pot Catalysis Using a Chiral Iridium Complex/Brønsted Base: Catalytic Asymmetric Synthesis of Catalponol
TL;DR: A two-step synthesis of catalponol was achieved using this sequential methodology together with regio- and stereoselective hydroboration for the synthesis of α-benzylidene-γ-hydroxytetralones with high ee's.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Release, storage and uptake of catecholamines by a clonal cell line of nerve growth factor (NGF) responsive pheochromocytoma cells
Lloyd A. Greene,Glen Rein +1 more
TL;DR: Findings indicate that PC12 cells can release catecholamines by means of an exocytotic secretion mechanism, store most of their endogenous catechlamines in chromaffin granules and/or vesicles and have an uptake1-type transport system for norepinephrine.
Journal Article
Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.
TL;DR: The PC12 cell, a clonal cell line derived from a pheochromocytoma of the rat adrenal medulla, provides an excellent model for studying chemical disruption of processes associated with neuronal differentiation, synthesis, storage and release of neurotransmitters, function and regulation of ion channels and interactions of compounds with membrane bound receptors.
Journal ArticleDOI
Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease.
G Walkinshaw,C M Waters +1 more
TL;DR: The finding that L-DOPA-induced cell death in vitro occurs via apoptosis explains the lack of evidence supporting its toxicity in vivo, since apoptotic neurons are rapidly phagocytosed in vivo without causing damage to surrounding tissue.
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