Journal ArticleDOI
Cell-Death Dependent Interleukin-1α Release Activates Host NLRP3 Inflammasome and Promotes Epithelial-Mesenchymal Transition in Metastatic Breast Cancer
Isak W. Tengesdal,Shaikh M. Atif,Makenna May,D. J. Mack,Andrew P. Fontenot,Leo A. B. Joosten,Charles A. Dinarello +6 more
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This article is published in Social Science Research Network.The article was published on 2022-01-01. It has received 0 citations till now. The article focuses on the topics: Inflammasome & Epithelial–mesenchymal transition.read more
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Activation and regulation of the inflammasomes
TL;DR: The complex regulatory mechanisms that facilitate a balanced but effective inflammasome-mediated immune response are discussed, and the similarities to another molecular signalling platform — the apoptosome — that monitors cellular health are highlighted.
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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
TL;DR: This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL- 1 family of ligands and receptors.
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IL-1 is required for tumor invasiveness and angiogenesis
Elena Voronov,Dror S. Shouval,Yakov Krelin,Emanuela Cagnano,Daniel Benharroch,Yoichiro Iwakura,Charles A. Dinarello,Ron N. Apte +7 more
TL;DR: The anti-angiogenic effects of IL-1 receptor antagonist, shown here, suggest a possible therapeutic role in cancer, in addition to its current use in rheumatoid arthritis.
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NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
Amna Abderrazak,Tatiana Syrovets,Dominique Couchie,Khadija El Hadri,Bertrand Friguet,Thomas Simmet,Mustapha Rouis,Mustapha Rouis,Mustapha Rouis +8 more
TL;DR: This review has updated knowledge on NLRP3 inflammasome assembly and activation and on the pyrin domain inNLRP3 that could represent a drug target to treat sterile inflammatory diseases, and reported mutations in NL RP3 that were found to be associated with certain diseases.
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Identification of a membrane-associated interleukin 1 in macrophages.
TL;DR: A surface membrane-associated interleukin 1 (IL-1) with potent thymocyte and T-cell stimulatory activity on peptone-elicited peritoneal macrophages is found and appears to be an integral membrane protein since it was solubilized by detergent but was not eluted by EDTA, high salt, or low pH treatment of the membranes.