Journal ArticleDOI
Cell Interaction in an Immune Response in vitro: Requirement for Theta-Carrying Cells
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Cytotoxic antiserum to theta antigen reduces the capacity of mouse spleen cells to generate direct and indirect plaque-forming cells to sheep erythrocytes in vitro but does not affect plaque- forming cells, their precursors, or hemopoietic stem cells.Abstract:
Cytotoxic antiserum to theta antigen reduces the capacity of mouse spleen cells to generate direct and indirect plaque-forming cells to sheep erythrocytes in vitro but does not affect plaque-forming cells, their precursors, or hemopoietic stem cells. The response of spleen cells treated with antiserum to theta antigen is restored by thymus cells incubated in vivo with sheep erythrocytes.read more
Citations
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Journal ArticleDOI
Separation of mouse spleen cells by passage through columns of sephadex G-10.
Iris A. Ly,Robert I. Mishell +1 more
TL;DR: Restoration experiments with peritoneal cells and 2-mercaptoethanol show that normal and antigen-primed T lymphocytes with helper function and B lymphocytes which are precursors of antibody-forming cells are present in substantial quantity in the effluent population.
Book ChapterDOI
The regulatory influence of activated T cells on B cell responses to antigen.
David H. Katz,Baruj Benacerraf +1 more
TL;DR: This chapter discusses the intimate mechanisms of the regulation of antibody responses by T cells, the significance of these phenomena for the regulatory processes of the immune system, and their possible implication for the pathogenesis of various immunopathological states.
Journal ArticleDOI
Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells.
TL;DR: This antiserum termed “anti-brain-associated Θ”, BAΘ, is cytotoxic to thymus cells but not marrow cells, inhibits the primary in vitro response to RBC, does not affect antibody-forming cells which are of marrow origin, and inhibits the graft-versus-host reaction.
Book ChapterDOI
Thymus-independent B-cell induction and paralysis.
A. Coutinho,Göran Möller +1 more
TL;DR: The main general conclusion concerning induction of paralysis by TI antigens is that specific B cells are turned off at higher concentrations of the TI antigen than those causing activation.
Book ChapterDOI
Is There Evidence for a Non-Antigen Specific Diffusable Chemical Mediator from the Thymus-Derived Cell in the Initiation of the Immune Response?
Richard W. Dutton,R M Falkoff,J.A. Hirst,Michael K. Hoffmann,John W. Kappler,J. Kettman,J. F. Lesley,D. Vann +7 more
TL;DR: In this article, the authors discuss evidence for a non-antigen specific diffusible chemical mediator from the thymus-derived cell in the initiation of the immune response.
References
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Journal ArticleDOI
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
TL;DR: Counts of macroscopic splenic colonies were used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells.
Journal ArticleDOI
Immunization of dissociated spleen cell cultures from normal mice
TL;DR: There is an increase in the ability to discriminate between different varieties of homologous erythrocytes and the in vitro response does not appear to be limited by whatever mechanisms regulate the in vivo response.
Journal ArticleDOI
The akr thymic antigen and its distribution in leukemias and nervous tissues
Arnold E. Reif,Joan M. Allen +1 more
TL;DR: A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct.
Journal ArticleDOI
Theta isoantigen as a marker of thymus-derived lymphocytes in mice.
TL;DR: In this paper, the theta (θ) isoantigen is determined by a single locus with two alleles: θAKR and RF mice and θC3H present in most other inbred strains of mice tested, which is found chiefly in thymus lymphocytes and brain, and to a lesser extent in peripheral lymphocytes in mice.
Journal ArticleDOI
Immunological activity of thymus and thoracic-duct lymphocytes.
TL;DR: In heavily irradiated mice, an inoculum containing a mixture of marrow and thymus cells allowed the production of more hemolysins against sheep erythrocytes than could be accounted for by summating the activities of each cell population alone.