Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging
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TLDR
New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions, and advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis.Abstract:
CNS lymphoma consists of 2 major subtypes: secondary CNS involvement by systemic lymphoma and PCNSL. Contrast-enhanced MR imaging is the method of choice for detecting CNS lymphoma. In leptomeningeal CNS lymphoma, representing two-thirds of secondary CNS lymphomas, imaging typically shows leptomeningeal, subependymal, dural, or cranial nerve enhancement. Single or multiple periventricular and/or superficial contrast-enhancing lesions are characteristic of parenchymal CNS lymphoma, representing one-third of secondary CNS lymphomas and almost 100% of PCNSLs. New CT and MR imaging techniques and metabolic imaging have demonstrated characteristic findings in CNS lymphoma, aiding in its differentiation from other CNS lesions. Advanced imaging techniques may, in the future, substantially improve the diagnostic accuracy of imaging, ultimately facilitating a noninvasive method of diagnosis. Furthermore, these imaging techniques may play a pivotal role in planning targeted therapies, prognostication, and monitoring treatment response.read more
Citations
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Imaging for Staging and Response Assessment in Lymphoma
TL;DR: An overview of the updated CT and PET response criteria for lymphoma staging and response assessment is provided to familiarize the radiologist with the most important and clinically relevant aspects of lymphoma imaging.
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Primary Central Nervous System Lymphoma and Atypical Glioblastoma: Multiparametric Differentiation by Using Diffusion-, Perfusion-, and Susceptibility-weighted MR Imaging
Philipp Kickingereder,Benedikt Wiestler,Benedikt Wiestler,Felix Sahm,Felix Sahm,Sabine Heiland,Matthias Roethke,Heinz Peter Schlemmer,Wolfgang Wick,Martin Bendszus,Alexander Radbruch,Alexander Radbruch +11 more
TL;DR: Combined evaluation of mean ADC, mean rCBV, and presence of ITSS allowed reliable differentiation of PCNSL and atypical glioblastoma in most patients, and these results support an integration of advanced MR imaging techniques for the routine diagnostic workup of patients with these tumors.
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A Systematic Approach to the Diagnosis of Suspected Central Nervous System Lymphoma
TL;DR: A combined stepwise systematic approach outlined here may facilitate an expeditious, comprehensive presurgical evaluation for cases of suspected CNS lymphoma.
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Primary central nervous system lymphoma and atypical glioblastoma: Differentiation using radiomics approach
Hie Bum Suh,Yoon Seong Choi,Sohi Bae,Sung Soo Ahn,Jong Hee Chang,Seok Gu Kang,Eui Hyun Kim,Se Hoon Kim,Seung Koo Lee +8 more
TL;DR: Large-scale radiomics with a machine-learning algorithm can be useful for differentiating PCNSL from atypical GBM, and yields a better diagnostic performance than human radiologists and ADC values.
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Diffusion radiomics as a diagnostic model for atypical manifestation of primary central nervous system lymphoma: development and multicenter external validation.
Daesung Kang,Ji Eun Park,Young Hoon Kim,Jeong Hoon Kim,Joo Young Oh,Jungyoun Kim,Yikyung Kim,Sung Tae Kim,Ho Sung Kim +8 more
TL;DR: The diffusion radiomics model had good generalizability and yielded a better diagnostic performance than conventional radiomics or single advanced MRI in identifying atypical PCNSL mimicking glioblastoma.
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