Change of serum antithyroglobulin antibody levels is useful for prediction of clinical recurrence in thyroglobulin-negative patients with differentiated thyroid carcinoma.
Won Gu Kim,Jong Ho Yoon,Won Bae Kim,Tae Yong Kim,Eui Young Kim,Jung Min Kim,Jin-Sook Ryu,Gyungyub Gong,Suck Joon Hong,Young Kee Shong +9 more
TLDR
Serum TgAb levels measured at 6-12 months after remnant ablation could predict recurrence in patients with undetectable thyroglobulin values, and a change in T gAb concentration during the early postoperative period may be a prognostic indicator of recurrence.Abstract:
Objectives: The aim of the study was to evaluate the usefulness of the antithyroglobulin autoantibody (TgAb) value at 6–12 months after remnant ablation in predicting recurrence in differentiated thyroid carcinoma patients who had undetectable thyroglobulin (Tg) values. The change in TgAb concentration measured between the time of remnant ablation (TgAb1) and 6–12 months thereafter (TgAb2) was also evaluated as a possible prognostic indicator. Patients and Methods: Patients with differentiated thyroid carcinoma who underwent total thyroidectomy followed by 131I remnant ablation between 1995 and 2003 at the Asan Medical Center (Seoul, Korea) were enrolled. Of these, 824 patients with undetectable Tg at 6–12 months after remnant ablation during thyroid hormone withdrawal were the subjects of this study. Results: TgAb2 was positive in 56 patients. Ten of 56 patients (18%) with positive TgAb2 had recurrence, whereas only 10 of 768 patients (1%) with negative TgAb2 had recurrence during 73.6 months of follow-u...read more
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2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.
Bryan R. Haugen,Erik K. Alexander,Keith C. Bible,Gerard M. Doherty,Susan J. Mandel,Yuri E. Nikiforov,Furio Pacini,Gregory W. Randolph,Anna M. Sawka,Martin Schlumberger,Kathryn G. Schuff,Steven I. Sherman,Julie Ann Sosa,David L. Steward,R. Michael Tuttle,Leonard Wartofsky +15 more
TL;DR: Evidence-based recommendations are developed to inform clinical decision-making in the management of thyroid nodules and differentiated thyroid cancer and represent, in the authors' opinion, contemporary optimal care for patients with these disorders.
Journal ArticleDOI
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Gary L. Francis,Steven G. Waguespack,Andrew J. Bauer,Peter Angelos,Salvatore Benvenga,Janete M. Cerutti,Catherine A. Dinauer,Jill Hamilton,Ian D. Hay,Markus Luster,Marguerite T. Parisi,Marianna Rachmiel,Geoffrey B. Thompson,Shunichi Yamashita +13 more
TL;DR: These inaugural guidelines provide recommendations for the evaluation and management of thyroid nodules in children and adolescents, including the role and interpretation of ultrasound, fine-needle aspiration cytology, and the management of benign nodules.
Journal ArticleDOI
Clinical Utility of Thyroglobulin Antibody (TgAb) Measurements for Patients with Differentiated Thyroid Cancers (DTC)
TL;DR: Although TgAb interferes with Tg IMA measurements, Tg Ab trends can be used as a surrogate DTC tumor marker in preference to TgIMA, provided that the same method is used.
Journal ArticleDOI
Thyroglobulin antibody is associated with increased cancer risk in thyroid nodules.
Eun Sook Kim,Dong Jun Lim,Ki Hyun Baek,Jongmin Lee,Mee Kyoung Kim,Hyuk-Sang Kwon,Ki Ho Song,Moo Ii Kang,Bong Yun Cha,Kwang Woo Lee,Ho Young Son +10 more
TL;DR: It is reported for the first time that a positive serum TgAb test was an independent predictor for thyroid malignancy in thyroid nodules along with serum TSH levels regardless of the presence of AIT.
Journal ArticleDOI
Implications of thyroglobulin antibody positivity in patients with differentiated thyroid cancer: a clinical position statement.
Frederik A. Verburg,Markus Luster,Cristina Cupini,Luca Chiovato,Leonidas H. Duntas,Rossella Elisei,Ulla Feldt-Rasmussen,Harald Rimmele,Ettore Seregni,Johannes W. A. Smit,Christian Theimer,Luca Giovanella +11 more
TL;DR: A thorough discussion by a group of physician-scientists, all of whom have a distinguished track record in thyroid cancer care, was held to arrive at a consensus expert opinion on how to proceed with treatment and follow-up in TgAb-positive DTC patients.
References
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Journal ArticleDOI
Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
Journal ArticleDOI
European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
Furio Pacini,Martin Schlumberger,Henning Dralle,Rossella Elisei,Johannes W. A. Smit,Wilmar M. Wiersinga +5 more
TL;DR: European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium Furio Pacini, Martin Schlumberger, Henning Dralle, Rossella Elisei, Johannes W A Smit, Wilmar Wiersinga and the European Thyroid Cancer Taskforce Section of Endocrinology and Metabolism are presented.
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Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease.
Zubair W. Baloch,Carayon P,Conte-Devolx B,Laurence M. Demers,Feldt-Rasmussen U,J. F. Henry,LiVosli Va,Niccoli-Sire P,John R,Jean Ruf,Smyth Pp,Spencer Ca,Stockigt +12 more
TL;DR: This revised monograph was achieved with the expert input of the editors, members of the guidelines committee, experts who submitted manuscripts for each section and many expert reviewers, who are listed in Appendix A.
Journal ArticleDOI
Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma.
Carole A. Spencer,M Takeuchi,M. Kazarosyan,C. C. Wang,Richard B. Guttler,Peter Singer,Shireen Fatemi,Jonathan S. LoPresti,John T. Nicoloff +8 more
TL;DR: The RIA method used in this study provided more clinically appropriate serum Tg values in the group of TgAb-positive patients with metastatic DTC and may be an additional clinically useful tumor marker parameter for following T gAb- positive patients.
Journal ArticleDOI
Is diagnostic iodine-131 scanning useful after total thyroid ablation for differentiated thyroid cancer?
TL;DR: A diagnostic 131I-TBS performed 1 yr after thyroid ablation demonstrated no abnormal uptake; it did not correlate with results of Tg determination and only confirmed the completeness of thyroid Ablation.