Journal ArticleDOI
Changes in corticosteroid synthesis of the human adrenal cortex in vitro, induced by treatment with o,p'-DDD for cushing's syndrome: evidence for the sites of action of the drug
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TLDR
The results clearly establish the inhibitory effect of o,p'-DDD on 11-hydroxylase and 18-hydroxycorticosterone activities in human adrenals of treated subjects.About:
This article is published in Journal of Steroid Biochemistry.The article was published on 1978-12-01. It has received 35 citations till now. The article focuses on the topics: Corticosterone & Adrenal cortex.read more
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The role of lipid peroxidation and biological antioxidants in the function of the adrenal cortex. Part 2
TL;DR: It will be suggested that, while lipid peroxidation is a process against which the adrenocortical cell must protect itself, it may also play a unique role in determining the differentiated properties of the adrenal cortex.
Journal ArticleDOI
Transsphenoidal pituitary surgery for the treatment of Cushing's disease: results in 64 patients and long term follow-up studies
Brigitte Guilhaume,Xavier Bertagna,Michèle Thomsen,Claire Bricaire,Evelyne Vila-Porcile,Léon Olivier,Jean Racadot,Patrick Derome,M.H. Laudat,François Girard,Bricaire H,Jean-Pierre Luton +11 more
TL;DR: Most of the patients in the immediate success group had transient ACTH deficiency preceding a progressive return to normal pituitary-adrenal function, and the probability of a patient remaining well 6 yr after surgery is 72 +/- 20% (95% confidence limit).
Journal ArticleDOI
Steroid and xenobiotic effects on the adrenal cortex: mediation by oxidative and other mechanisms
TL;DR: Cytochrome P450/pseudosubstrate effects could be involved in the aging and death of adrenocortical cells in vivo, and necrosis of the adrenal cortex due to excessive ACTH stimulation or due to the action of adrenolytic chemicals could result from damage by oxygen radicals originating from cytochromeP450s.
Journal ArticleDOI
Future directions in the diagnosis and medical treatment of adrenocortical carcinoma
Sara G Creemers,Leo J. Hofland,Esther Korpershoek,Gaston J H Franssen,F. J. van Kemenade,W. W. de Herder,Richard A Feelders +6 more
TL;DR: New markers like Ki67, a marker for proliferation, and the staining of reticulins are promising not only as it comes to identifying malignancy but also as prognostic markers in patients with ACC, which appears to harbor many abnormalities compared to ACAs.
Journal ArticleDOI
Management of adrenocortical carcinoma: a consensus statement of the Italian Society of Endocrinology (SIE)
Antonio Stigliano,Iacopo Chiodini,Roberta Giordano,Antongiulio Faggiano,Letizia Canu,S Della Casa,Paola Loli,Michaela Luconi,Franco Mantero,Massimo Terzolo +9 more
TL;DR: The Italian Society of Endocrinology appointed a panel of Italian experts in the field of adrenal diseases with the task to write a Position Statement whose intent was to review and synthesize currently available evidence regarding ACC and provide information on presenting symptoms.
References
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Journal ArticleDOI
Double isotope derivative assay of aldosterone in biological extracts.
TL;DR: This report includes a detailed description of the method, assay results for human urine and dog adrenal vein plasma, and a critical evaluation of the specificity, precision, and accuracy of this technique.
Journal ArticleDOI
Results of treatment in 108 patients with Cushing's syndrome.
David N. Orth,Grant W. Liddle +1 more
TL;DR: Except in patients with ectopic ACTH syndrome or adrenal carcinoma, appropriate treatment for Cushing's syndrome is appropriate, except in patients that respond metabolically to metyrapone.
Journal ArticleDOI
Adrenal cortical carcinoma: Clinical features of 138 patients
TL;DR: Survival curves suggest that female patients live longer than male patients and that patients with normal steroid excretion live more than those with increased excretion, and primary treatment of adrenal carcinoma should be surgical removal of the tumor whenever possible.
Journal ArticleDOI
Adrenal Cortical Carcinoma* Results of Treatment with o,p'DDD in 138 Patients
TL;DR: It is concluded that o,p'DDD is indicated in the treatment of inoperable patients with both functioning and nonfunctioning adrenal carcinoma, with a correlation between measurable disease response and prolongation of life.
Journal ArticleDOI
CHEMOTHERAPY OF ADRENOCORTICAL CANCER WITH o,p′DDD
TL;DR: The approach to the chemotherapy of adrenocortical carcinoma is based upon the original observations of Nelson and Woodard, which observed that the oral administration to dogs of the insecti...
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