Journal ArticleDOI
Characterization and phylogenetic relationship of prosimian MHC class I genes.
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TLDR
In gene tree analysis, the strepsirrhine class Ia genes described here cluster significantly separately from the known class I genes of Catarrhini and Platyrrhini species, suggesting that the class I loci of Simiiformes arose by gene duplications which occurred after the divergence of prosimians.Abstract:
MHC class I cDNA sequences from the most divergent primate group of extant primates compared to human, the suborder Strepsirrhini (prosimians), are described. The sequences are derived from the gray mouse lemur (Microcebus murinus) and the ring-tailed lemur (Lemur catta), which are members of the malagasy Lemuriformes, as well as from the pygmy slow loris (Nycticebus pygmaeus), a prosimian from East Asia. The M. murinus sequences have been analyzed in detail. Analysis of the expression level, G/C content, and synonymous vs. nonsynonymous substitution rates in the peptide-binding region codons suggests that these cDNA clones represent classical class I (class Ia) genes. According to Southern blot analysis, the genome of the gray mouse lemur might contain about 10 class I genes. In gene tree analysis, the strepsirrhine class Ia genes described here cluster significantly separately from the known class I genes of Catarrhini (humans, apes, Old World monkeys) and Platyrrhini (New World monkeys) species, suggesting that the class I loci of Simiiformes arose by gene duplications which occurred after the divergence of prosimians.read more
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Journal ArticleDOI
Comparative genomics of major histocompatibility complexes
TL;DR: This review compares maps of MHC gene orders in commonly studied species, where extensive sequencing has been performed, and suggests rapid evolution of M HC genes after divergence from a common ancestor.
Journal ArticleDOI
Co‐evolution of MHC class I and variable NK cell receptors in placental mammals
TL;DR: A survey of placental mammals suggests that KIRs serve as variable NK cell receptors only in certain primates and artiodactyls, and identifies the functionally distinctive KIR A and KIR B haplotypes.
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A novel system of polymorphic and diverse NK cell receptors in primates.
Anne Averdam,Beatrix Petersen,Cornelia Rosner,Jennifer Neff,Christian Roos,Manfred Eberle,Fabienne Aujard,Claudia Münch,Werner Schempp,Mary Carrington,Takashi Shiina,Hidetoshi Inoko,Florian Knaust,Penny Coggill,Harminder Sehra,Stephan Beck,Laurent Abi-Rached,Richard Reinhardt,Lutz Walter +18 more
TL;DR: The data support the existence of a hitherto unknown system of polymorphic and diverse NK cell receptors in primates and of combinatorial diversity as a novel mechanism to increase NK cell receptor repertoire.
Journal ArticleDOI
Primate-specific regulation of natural killer cells.
Peter Parham,Laurent Abi-Rached,Lilit Matevosyan,Achim K. Moesta,Paul Norman,Anastazia M. Older Aguilar,Lisbeth A. Guethlein +6 more
TL;DR: The authors' studies of KIR and MHC class I genes in representative species show how these two unlinked but functionally intertwined genetic complexes have co‐evolved.
Journal ArticleDOI
Frequent segmental sequence exchanges and rapid gene duplication characterize the MHC class I genes in lemurs.
Yasuhiro Go,Yasuhiro Go,Yoko Satta,Yoshi Kawamoto,Gilbert Rakotoarisoa,Albert Randrianjafy,Naoki Koyama,Hirohisa Hirai +7 more
TL;DR: Phylogenetic analysis indicates that nucleotide diversity among loci was very small and the persistence time of the polymorphisms was short, suggesting that the origin of the lemur MHC class I genes detected in this study was relatively recent.
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