Journal ArticleDOI
Chemical modification of hyaluronic acid by carbodiimides.
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TLDR
The degree of conversion to NaHA-acylurea products appears to depend upon both the characteristics of various carbodiimides and the conformational structure of NaHA.About:
This article is published in Bioconjugate Chemistry.The article was published on 1991-07-01. It has received 207 citations till now. The article focuses on the topics: Chemical modification & Diamine.read more
Citations
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Journal ArticleDOI
Steric Stabilization of a Cellulose Microcrystal Suspension by Poly(ethylene glycol) Grafting
TL;DR: A sterically stabilized aqueous suspension of rod-like cellulose microcrystals was prepared by the combination of acid hydrolysis of native cellulose, oxidative carboxylation of micro-crystals, and grafting of poly(ethylene glycol) having a terminal amino group on one end (PEG-NH2, MW = 1000) using water-soluble carbodiimide as discussed by the authors.
Journal ArticleDOI
Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery.
TL;DR: A new hyaluronic acid (HA)-based hydrogel film was prepared and evaluated for use in drug delivery and can be employed for controlled release of therapeutic agents at wound sites.
Journal ArticleDOI
New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels.
Paul Bulpitt,Daniel Aeschlimann +1 more
TL;DR: A versatile method for chemical crosslinking high-molecular-weight hyaluronic acid under physiological conditions yielding biocompatible and biodegradable hydrogels is developed.
Journal ArticleDOI
Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications
TL;DR: The purpose of this paper is to review the various chemical modification methods and synthetic routes to obtain HA derivatives, encompassing all applications.
Journal ArticleDOI
Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives.
Eun Ju Oh,Kitae Park,Ki Su Kim,Jiseok Kim,Jeong-A Yang,Ji-Hyun Kong,Min-Young Lee,Allan S. Hoffman,Sei Kwang Hahn +8 more
TL;DR: A peer overview on novel HA derivatives and the latest advances in HA-based drug delivery systems of various biopharmaceuticals for further clinical development is given.
References
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Journal ArticleDOI
Advances in the chemistry of carbodiimides.
Book ChapterDOI
[56] Carbodiimide modification of proteins.
K.L. Carraway,D.E. Koshland +1 more
TL;DR: A carbodiimide-nucleophile procedure for modifying carboxyl groups in proteins can be utilized under mild conditions for the quantitative determination of all carboxy groups or for the modification of selected residues in activity studies.
Journal ArticleDOI
Affinity chromatography on immobilized hyaluronate and its application to the isolation of hyaluronate binding proteins from cartilage
TL;DR: Partially degraded hyaluronate was coupled to AH-Sepharose 4B using carbodiimide and the derivatized gel was used to purify components of the hyAluronate-proteoglycan complex of cartilage.
Related Papers (5)
New strategy for chemical modification of hyaluronic acid: preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels.
Paul Bulpitt,Daniel Aeschlimann +1 more