Journal ArticleDOI
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis.
Laszlo J. Karai,Marshall E. Kadin,Eric D. Hsi,Jason C. Sluzevich,Rhett P. Ketterling,Ryan A. Knudson,Andrew L. Feldman +6 more
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TLDR
The benign clinical course in all 11 patients despite pathologic features mimicking an aggressive lymphoma emphasizes the importance of clinicopathologic correlation, incorporating molecular genetic analysis when possible, during the evaluation of cutaneous lymphoproliferative disorders.Abstract:
Lymphomatoid papulosis (LyP) is an indolent cutaneous lymphoproliferative disorder with clinical and pathologic features overlapping those of both reactive conditions and aggressive lymphomas. Recurrent genetic abnormalities in LyP have not been previously identified. Here, we describe the clinical, immunophenotypic, and genetic characteristics of cutaneous lymphoproliferative lesions showing distinctive and previously undescribed histologic features in 11 patients. All patients were older adults (67 to 88 y) with predominantly localized lesions and clinical presentations suggesting benign inflammatory dermatoses or low-grade epithelial tumors. Histologically, lesions showed a biphasic growth pattern, with small cerebriform lymphocytes in the epidermis and larger transformed lymphocytes in the dermis. All had a T-cell immunophenotype. The pathologic features raised the possibility of an aggressive T-cell lymphoma such as transformed mycosis fungoides. However, no patient developed disseminated skin disease or extracutaneous spread. Untreated lesions regressed spontaneously. All cases harbored chromosomal rearrangements of the DUSP22-IRF4 locus on 6p25.3. The overall findings suggest that these cases represent a newly recognized LyP subtype characterized by 6p25.3 rearrangements. The benign clinical course in all 11 patients despite pathologic features mimicking an aggressive lymphoma emphasizes the importance of clinicopathologic correlation, incorporating molecular genetic analysis when possible, during the evaluation of cutaneous lymphoproliferative disorders.read more
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The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TL;DR: The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.
Journal ArticleDOI
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas
Rein Willemze,Lorenzo Cerroni,Werner Kempf,Emilio Berti,Fabio Facchetti,Steven H. Swerdlow,Elaine S. Jaffe +6 more
TL;DR: The characteristic features of these new and modified entities as well as the results of recent molecular studies with diagnostic, prognostic, and/or therapeutic significance for the different types of primary cutaneous lymphomas are reviewed.
Journal ArticleDOI
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes
Edgardo R. Parrilla Castellar,Elaine S. Jaffe,Jonathan W. Said,Steven H. Swerdlow,Rhett P. Ketterling,Ryan A. Knudson,Jagmohan S. Sidhu,Eric D. Hsi,Shridevi Karikehalli,Liuyan Jiang,George Vasmatzis,Sarah E. Gibson,Sarah L. Ondrejka,Alina Nicolae,Karen L. Grogg,Cristine Allmer,Kay M. Ristow,Wyndham H. Wilson,William R. Macon,Mark E. Law,James R. Cerhan,Thomas M. Habermann,Stephen M. Ansell,Ahmet Dogan,Matthew J. Maurer,Andrew L. Feldman +25 more
TL;DR: ALK-negative ALCL is a genetically heterogeneous disease with widely disparate outcomes following standard therapy, and DUSP22 and TP63 rearrangements may serve as predictive biomarkers to help guide patient management.
Journal ArticleDOI
Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous.
Xiaoming Xing,Andrew L. Feldman +1 more
TL;DR: The clinical, morphologic, phenotypic, genetic, and biological features of ALCLs are discussed, including chromosomal rearrangements involving the ALK gene with varied gene partners and a favorable prognosis.
Journal ArticleDOI
Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms.
TL;DR: The 2016 revisions in the WHO classification particularly impact T-cell lymphomas, including a new umbrella category of T-follicular helper cell-derived lymphomas and evolving recognition of indolent T-cells and lymphoproliferative disorders.
References
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Journal ArticleDOI
WHO-EORTC classification for cutaneous lymphomas.
Rein Willemze,Elaine S. Jaffe,Günter Burg,Lorenzo Cerroni,Emilio Berti,Steven H. Swerdlow,Elisabeth Ralfkiaer,Sergio Chimenti,José Luis Diaz-Perez,Lyn M. Duncan,Florent Grange,Nancy L. Harris,Werner Kempf,Helmut Kerl,Michael O. Kurrer,Robert Knobler,Nicola Pimpinelli,Chris Sander,Marco Santucci,Wolfram Sterry,Maarten H. Vermeer,Janine Wechsler,Sean Whittaker,Chris J.L.M. Meijer +23 more
TL;DR: The characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin are described, and differences with the previous classification schemes are discussed.
Journal ArticleDOI
Primary and secondary cutaneous CD30+lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment
Marcel W. Bekkenk,Françoise A. M. J. Geelen,Pieter C. van Voorst Vader,F. Heule,M.L. Geerts,Willem A. van Vloten,Chris J.L.M. Meijer,Rein Willemze +7 more
TL;DR: Clinical and long-term follow-up data indicate that CD30(+) LTCL on the skin and in 1 draining lymph node station has a good prognosis similar to that for primary cutaneous CD30 (+) L TCL without concurrent lymph node involvement.
Journal ArticleDOI
ALK-Positive Lymphoma: A Single Disease With a Broad Spectrum of Morphology
Daniel Benharroch,Zarouhie Meguerian-Bedoyan,Laurence Lamant,Chauki Amin,Laurence Brugières,Marie Jose Terrier-Lacombe,Eugenia Haralambieva,Karen Pulford,Stefano Pileri,Stephan W. Morris,David Y. Mason,Georges Delsol +11 more
TL;DR: It is concluded from this study that ALK-positive neoplasms represent a distinct entity and should henceforward be referred to as ALK lymphomas.
Journal ArticleDOI
Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior
Emilio Berti,Dario Tomasini,Maarten H. Vermeer,Chris J.L.M. Meijer,Elvio Alessi,Rein Willemze +5 more
TL;DR: In this article, the clinical, histological, and immunophenotypical features of 17 CD8+ CTCL were reviewed, and the results indicated that these strongly epidermotropic primary cutaneous CD8+, cytotoxic T cell lymphomas represent a distinct type of CTCCL with an aggressive clinical behavior.
Journal ArticleDOI
Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant.
TL;DR: A 41-year-old woman has an asymptomatic eruption of three years' duration that shows an alarming infiltrate of anaplastic cells of disputatious origin, suggesting a diagnosis of malignant lymphoma.
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