Journal ArticleDOI
Chromosome aberrations in B-cell chronic lymphocytic leukemia: Pathogenetic and clinical implications
Gunnar Juliusson,Gösta Gahrton +1 more
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TLDR
Chromosome analyses were performed on leukemic cells from 102 patients with B-CLL, of whom 84 were untreated and 55 showed clonal chromosomal aberrations, and those with 14q + or trisomy 12 tended to have slightly poorer prognosis andThose with 6q- or structural aberration involving the long arm of chromosome 13 tended toHave better prognosis than patients with other chromosomalAberrations.About:
This article is published in Cancer Genetics and Cytogenetics.The article was published on 1990-04-01. It has received 139 citations till now. The article focuses on the topics: Complex Karyotype & Trisomy.read more
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Journal ArticleDOI
p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias.
Hartmut Döhner,K. Fischer,Martin Bentz,Katrin Hansen,Axel Benner,Georges Cabot,Daniela Diehl,Richard F. Schlenk,Johannes F. Coy,Stephan Stilgenbauer,Martin Volkmann,Peter R. Galle,Annemarie Poustka,Werner Hunstein,Peter Lichter +14 more
TL;DR: In multivariate analysis, p53 gene deletion was the strongest prognostic factor for survival and predicts for non-response to therapy with purine analogs and for poor survival in chronic B-cell leukemias.
Journal ArticleDOI
Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.
Gunnar Juliusson,David Oscier,Margaret Fitchett,Fiona M. Ross,George Stockdill,Michael J. Mackie,A. Parker,Gian Luigi Castoldi,Antonio Cuneo,Sakari Knuutila,Erkki Elonen,Gösta Gahrton +11 more
TL;DR: Chromosomal analysis provides prognostic information about overall survival in addition to that supplied by clinical data in patients with B-cell CLL.
Journal ArticleDOI
11q Deletions Identify a New Subset of B-Cell Chronic Lymphocytic Leukemia Characterized by Extensive Nodal Involvement and Inferior Prognosis
Hartmut Döhner,Stephan Stilgenbauer,Michael R. James,Axel Benner,Traudel Weilguni,Martin Bentz,K. Fischer,Werner Hunstein,Peter Lichter +8 more
TL;DR: 11q deletions identify a new clinical subset of B-CLL characterized by extensive lymph node involvement and strongly depended on the age: in patients less than 55 years old, the median survival time was significantly shorter in the deletion group (64 months v 209 months; P < .001), whereas in patients > or =55 years old there was no significant difference (94 months v 111 months).
Journal ArticleDOI
Genetics of chronic lymphocytic leukemia: genomic aberrations and V H gene mutation status in pathogenesis and clinical course
TL;DR: Genetic aberrations and VH mutation status appear to give prognostic information irrespective of the clinical stage and may therefore allow a risk assessment for individual patients early in the course of their disease.
Journal ArticleDOI
Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.
Christine Mayr,Michael R. Speicher,David M. Kofler,Raymund Buhmann,John Strehl,Raymonde Busch,Michael Hallek,Clemens-Martin Wendtner +7 more
TL;DR: A new subgroup of patients with CLL defined by chromosomal trans-locations and poor prognosis is identified, and complex karyotype, CD38 expression, and 17p deletions-translocation proved to be the prognostic marker with the highest impact for an unfavorable clinical outcome.
References
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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
Journal Article
An international system for human cytogenetic nomenclature
TL;DR: An exceptional reading e-book entitled International System For Human Cytogenetic Nomenclature provides a thorough legal analysis and guidance to state authorities, human rights and humanitarian actors and others.
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Clinical staging of chronic lymphocytic leukemia.
Kanti R. Rai,Arthur Sawitsky,Eugene P. Cronkite,Arjun D. Chanana,Robert N. Levy,Bernard S. Pasternack +5 more
TL;DR: The proposed staging system was an equally accurate indicator for survival when applied to two other previously published studies of large series of patients and sex and age were shown to be poor predictors of survival after adjustment for stage.
Journal ArticleDOI
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Yoshihide Tsujimoto,Lawrence R. Finger,Jorge J. Yunis,Peter C. Nowell,Carlo M. Croce,Carlo M. Croce +5 more
TL;DR: In this paper, a DNA probe was obtained from an acute B-cell leukemia cell line, which was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14.