Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TLDR
These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).About:
This article is published in Hepatology.The article was published on 2001-12-01 and is currently open access. It has received 2790 citations till now. The article focuses on the topics: Hepatitis B & Health care.read more
Citations
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A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
Chun-Tao Wai,Joel K. Greenson,Robert J. Fontana,John D. Kalbfleisch,Jorge A. Marrero,Hari S. Conjeevaram,Anna S.F. Lok +6 more
TL;DR: It is shown that a simple index using readily available laboratory results can identify CHC patients with significant fibrosis and cirrhosis with a high degree of accuracy and may decrease the need for staging liver biopsy specimens among patients with CHC.
Journal ArticleDOI
Diagnosis, management, and treatment of hepatitis C: An update
TL;DR: This document has been approved by the AASLD, the Infectious Diseases Society of America, and the American College of Gastroenterology.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Journal ArticleDOI
Chronic hepatitis B: Update 2009
Anna S.F. Lok,Brian J. McMahon +1 more
TL;DR: The 2009 update of the American Association for the Study of Liver Diseases (AASLD) Practice Guidelines for Management of Chronic Hepatitis B is now posted online at www.aasld.org, and the recommendation for first-line oral antiviral medications has been changed to tenofovir or entecavir, and adefovir has been moved to second-line Oral antiviral medication.
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Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease
Yun-Fan Liaw,Joseph J.Y. Sung,Wan Cheng Chow,Geoffrey C. Farrell,Cha-Ze Lee,Hon Yuen,Tawesak Tanwandee,Qi-Min Tao,Kelly Shue,Oliver N. Keene,Jonathan S. Dixon,D. Fraser Gray,Jan Sabbat +12 more
TL;DR: Continuous treatment with lamivudine delays clinical progression in patients with chronic hepatitis B and advanced fibrosis or cirrhosis by significantly reducing the incidence of hepatic decompensation and the risk of hepatocellular carcinoma.
References
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Journal ArticleDOI
Histological grading and staging of chronic hepatitis.
Kamal G. Ishak,Amelia Baptista,Leonardo Bianchi,Francesco Callea,Jan De Groote,Fred Gudat,Helmut Denk,Valeer Desmet,Gerhard Korb,R. N. M. Macsween,M. James Phillips,Bernard G. Portmann,H. Poulsen,Peter J. Scheuer,Martin Schmid,Heribert Thaler +15 more
TL;DR: This research presents a meta-analysis of Anatomia e Istologia Patologica, a large quantity of which has never before been published in a peer-reviewed journal, which aims to provide real-time information about the immune system’s response to disease.
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Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
Robert G. Knodell,Kamal G. Ishak,William C. Black,Thomas S. Chen,Robert M. Craig,Neil Kaplowitz,T Kiernan,Jerome Wollman +7 more
TL;DR: A Histology Activity Index has been developed which generates a numerical score for liver biopsy specimens obtained from patients with asymptomatic chronic active hepatitis that provides definitive endpoints for statistical analysis of serial changes in liver histology and offers an alternative to the use of conventional pathological descriptions.
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Hepatitis B virus infection.
TL;DR: This review addresses many aspects of HBV infection, including the role of the immune system in determining the outcome of clinical infection, recent developments in molecular studies of the virus, and new treatments capable of eradicating chronic infection.
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Classification of chronic hepatitis: diagnosis, grading and staging.
TL;DR: Recombinant human alpha-interferon in patients with chronic nonA-nonB hepatitis and factors predictive of response to interferon alpha therapy in HCV infection are studied.
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A One-Year Trial of Lamivudine for Chronic Hepatitis B
Ching-Lung Lai,R.-N. Chien,N. W. Y. Leung,Ting-Tsung Chang,R. Guan,D.-I. Tai,K.-Y. Ng,P.-C. Wu,Julie C. Dent,J. Barber,S. L. Stephenson,D. F. Gray +11 more
TL;DR: In a one-year study, lamivudine was associated with substantial histologic improvement in many patients with chronic hepatitis B, and a daily dose of 100 mg was more effective than a daily doses of 25 mg.