N
Nicholas M. Barnes
Researcher at University of Birmingham
Publications - 134
Citations - 8194
Nicholas M. Barnes is an academic researcher from University of Birmingham. The author has contributed to research in topics: Receptor & 5-HT3 receptor. The author has an hindex of 37, co-authored 123 publications receiving 7280 citations. Previous affiliations of Nicholas M. Barnes include National Institute for Health Research & University of Bradford.
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Journal ArticleDOI
A review of central 5-HT receptors and their function
Nicholas M. Barnes,Trevor Sharp +1 more
TL;DR: A number of 5-HT receptor ligands are currently utilised, or are in clinical development, to reduce the symptoms of CNS dysfunction and the functional responses attributed to each receptor in the brain are reviewed.
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Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis
TL;DR: A significant elevation in pro- inflammatory cytokine levels in the serum of patients with medication-naive first episode psychosis adds to the evidence of a pro-inflammatory immune deregulation in schizophrenia and suggests these cytokines should be the focus for further research in biomarkers of progress and extent of illness.
Journal ArticleDOI
5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue.
TL;DR: Evidence that a reduction in cortical cholinergic function can be effected in vitro by 5-HT3 receptors is provided and Radioligand binding studies show a high density of 5- HT3 receptors in theCholinergic-rich entorhinal cortex.
Journal ArticleDOI
The 5-HT3 receptor--the relationship between structure and function.
TL;DR: The relationship between the structure and the function of the 5-HT3 receptor is reviewed, describing recent studies that have identified numerous HTR3A and H TR3B gene polymorphisms that impact upon 5- HT3 receptor function, or expression, and consider their relevance to (patho)physiology.
Journal ArticleDOI
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
Stephen P.H. Alexander,Arthur Christopoulos,Anthony P. Davenport,Eamonn Kelly,Alistair Mathie,John A. Peters,Emma L. Veale,Jane F. Armstrong,Elena Faccenda,Simon D. Harding,Adam J. Pawson,Christopher Southan,Jamie A. Davies,Maria P. Abbracchio,Wayne R. Alexander,Khaled A. Al-Hosaini,Magnus Bäck,Nicholas M. Barnes,Ross A. D. Bathgate,Jean-Martin Beaulieu,Kenneth E. Bernstein,Bernhard Bettler,Nigel J. M. Birdsall,Victoria A. Blaho,François Boulay,Corinne Bousquet,Hans Bräuner-Osborne,Geoffrey Burnstock,Girolamo Calò,Justo P. Castaño,Kevin J. Catt,Stefania Ceruti,Paul L. Chazot,Nan Chiang,Bice Chini,Jerold Chun,Antonia Cianciulli,Olivier Civelli,Lucie H. Clapp,Réjean Couture,Zsolt Csaba,Claes Dahlgren,Gordon Dent,Khuraijam Dhanachandra Singh,Steven D. Douglas,Pascal Dournaud,Satoru Eguchi,Emanuel Escher,Edward J. Filardo,Tung Fong,Marta Fumagalli,Raul R. Gainetdinov,Marc de Gasparo,Craig Gerard,Marvin C. Gershengorn,Fernand Gobeil,Theodore L. Goodfriend,Cyril Goudet,Karen J. Gregory,Andrew L. Gundlach,Jörg Hamann,Julien Hanson,Richard L. Hauger,Debbie L. Hay,Akos Heinemann,Morley D. Hollenberg,Nicholas D. Holliday,Mastgugu Horiuchi,Daniel Hoyer,László Hunyady,Ahsan Husain,Adriaan P. IJzerman,Tadashi Inagami,Kenneth A. Jacobson,Robert T. Jensen,Ralf Jockers,Deepa Jonnalagadda,Sadashiva S. Karnik,Klemens Kaupmann,Jacqueline R. Kemp,Charles Kennedy,Yasuyuki Kihara,Takio Kitazawa,Paweł Kozielewicz,Hans-Jürgen Kreienkamp,Jyrki P. Kukkonen,Tobias Langenhan,Katie Leach,Davide Lecca,John D. Lee,Susan E. Leeman,Jérôme Leprince,Xaria X. Li,Thomas L Williams,Stephen J Lolait,Amelie Lupp,Robyn Macrae,Janet J. Maguire,Jean Mazella,Craig A. McArdle,Shlomo Melmed,Martin C. Michel,Laurence J. Miller,Vincenzo Mitolo,Bernard Mouillac,Christa E. Müller,Philip N. Murphy,Jean-Louis Nahon,Tony Ngo,Xavier Norel,Duuamene Nyimanu,Anne Marie O'Carroll,Stefan Offermanns,Maria Antonietta Panaro,Marc Parmentier,Roger G. Pertwee,Jean-Philippe Pin,Eric R. Prossnitz,Mark T. Quinn,Rithwik Ramachandran,Manisha Ray,Rainer K. Reinscheid,Philippe Rondard,G. Enrico Rovati,Chiara Ruzza,Gareth J. Sanger,Torsten Schöneberg,Gunnar Schulte,Stefan Schulz,Deborah L. Segaloff,Charles N. Serhan,Leigh A. Stoddart,Yukihiko Sugimoto,Roger J. Summers,Valerie P. Tan,David M. Thal,Walter G. Thomas,Pieter Timmermans,Kalyan C. Tirupula,Giovanni Tulipano,Hamiyet Unal,Thomas Unger,Celine Valant,Patrick Vanderheyden,David Vaudry,Hubert Vaudry,Jean-Pierre Vilardaga,Christopher S. Walker,Ji Ming Wang,Donald T. Ward,Hans-Jürgen Wester,Gary B. Willars,Trent M. Woodruff,Chengcan Yao,Richard D. Ye +154 more
TL;DR: The Concise Guide to PHARMACOLOGY 2021/22 as mentioned in this paper provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands.