Journal ArticleDOI
Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs
Marek L. Kowalski,Riccardo Asero,Sevim Bavbek,Miguel Blanca,Natalia Blanca-López,Grazyna Bochenek,Knut Brockow,Paloma Campo,Gülfem Çelik,Josefina Cernadas,G Cortellini,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Andrzej Szczeklik,S. Testi,María José Torres,Stefan Wöhrl,Joanna Makowska +18 more
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TLDR
This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs.Abstract:
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ manifestations, and severity, involving either immunological (allergic) or nonimmunological mechanisms. Proper classification of reactions based on clinical manifestations and suspected mechanism is a prerequisite for the implementation of rational diagnostic procedures and adequate patient management. This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs. The document proposes also practical algorithms for the diagnosis of specific types of NSAIDs hypersensitivity (which include drug provocations, skin testing and in vitro testing) and provides, when data are available, evidence-based recommendations for the management of hypersensitive patients, including drug avoidance and drug desensitization.read more
Citations
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Journal ArticleDOI
Two approaches for diagnosis of nonsteroidal anti-inflammatory drug hypersensitivity in children.
TL;DR: Performing an initial OPT with ASA regardless of patients' reaction history can result in much lower numbers of OPT to diagnose NSAID-H and can improve patient compliance.
Journal ArticleDOI
Lymphocyte Transformation Test for drug allergy detection: when does it work?
TL;DR: In this paper , the authors investigated the impact of different patient-specific and methodological parameters on the sensitivity of the lymphocyte transformation test (LTT) based on data on the level of the individual patient extracted from single studies.
Journal ArticleDOI
The using of a piglets as a model for evaluating the dipyrone hematological effects.
TL;DR: Observations suggest that a piglet model is useful for studying the impact of MET on hemorheological parameters, and significant impact ofMET treatment was proven in case of activated partial thromboplastin time.
Journal ArticleDOI
Hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) - a retrospective study.
Flavia Angeletti,Franziska Meier,Nadja Zöller,Markus Meissner,Roland Kaufmann,Eva Maria Valesky +5 more
TL;DR: The aim of this study was to verify the validity of clinical history and oral provocation challenges of patients with NSAID hypersensitivity and to identify safe alternatives.
Journal ArticleDOI
Skin testing and drug provocation tests in epidermal necrolysis: a French experience.
Camille Roux,B. Ben Said,Brigitte Milpied,Claire Bernier,Delphine Staumont-Sallé,F. Dezoteux,Angèle Soria,Annick Barbaud,Laurence Valeyrie-Allanore,Florence Tetart,N. Bellon,Bénédicte Lebrun-Vignes,G. Gener,Muriel Paul,Saskia Ingen-Housz-Oro,Haudrey Assier +15 more
TL;DR: In this paper , the authors report a French multicenter experience in skin testing and challenges in epidermal necrolysis, and investigate the factors associated with tests' positivity.
References
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Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Munir Pirmohamed,Sally James,Shaun Meakin,Chris D. Green,A Scott,Tom Walley,Keith Farrar,B. Kevin Park,Alasdair Breckenridge +8 more
TL;DR: The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.
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A new system for grading recommendations in evidence based guidelines
Robin Harbour,Juliet Miller +1 more
TL;DR: A revised system of determining levels of evidence and grades for guideline recommendations is published, based on the work of the US Agency for Healthcare Research and Quality and its applicability to the target population of the guideline.
Journal ArticleDOI
Intolerance to Aspirin: Clinical Studies and Consideration of its Pathogenesis
Max Samter,Ray F. Beers +1 more
Journal ArticleDOI
Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.
Werner Aberer,Andreas J. Bircher,Antonino Romano,Miguel Blanca,Paolo Campi,Javier Fernández,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself.
Journal ArticleDOI
Delayed Drug Hypersensitivity Reactions
TL;DR: This review presents newer concepts of the role of T cells in drug hypersensitivity, which evolved from the study of drug-specific T Cells in various drug-induced hypersensitivity diseases.
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