Journal ArticleDOI
Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs
Marek L. Kowalski,Riccardo Asero,Sevim Bavbek,Miguel Blanca,Natalia Blanca-López,Grazyna Bochenek,Knut Brockow,Paloma Campo,Gülfem Çelik,Josefina Cernadas,G Cortellini,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Andrzej Szczeklik,S. Testi,María José Torres,Stefan Wöhrl,Joanna Makowska +18 more
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TLDR
This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs.Abstract:
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ manifestations, and severity, involving either immunological (allergic) or nonimmunological mechanisms. Proper classification of reactions based on clinical manifestations and suspected mechanism is a prerequisite for the implementation of rational diagnostic procedures and adequate patient management. This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs. The document proposes also practical algorithms for the diagnosis of specific types of NSAIDs hypersensitivity (which include drug provocations, skin testing and in vitro testing) and provides, when data are available, evidence-based recommendations for the management of hypersensitive patients, including drug avoidance and drug desensitization.read more
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Book ChapterDOI
Cutaneous Drug Hypersensitivity: Clinical Features, Mechanism, Diagnosis, and Management in Children and Adolescent
Journal ArticleDOI
Histopathological Changes Of Inferior Turbinate In Patients With Allergic And Non allergic Rhinitis
TL;DR: Assessment of the thickness of the medial and lateral mucosal layers of inferior turbinate with AR and NAR found significant increase in eosinophiles and mast cells in AR and non specific inflammatory cells in NAR.
Journal Article
Nonsteroidal anti-inflammatory drug administration in children with history of wheeze.
Kendra Sih,Ran D. Goldman +1 more
TL;DR: A child who recently sprained his ankle is experiencing pain and having trouble bearing weight on the affected leg, as his mother has been giving him acetaminophen, as she was told never to use nonsteroidal anti-inflammatory drugs (NSAIDs) because of his pharmacologically controlled asthma.
Journal ArticleDOI
Anaphylaxis to nimesulide.
Reacţii de hipersensibilitate la antiinflamatorii nesteroidiene: scurtă actualizare
TL;DR: Oral challenge with NSAID is the “gold standard“ for the diagnosis and can be performed in order to confirm hypersensitivity to the culprit drug or to confirm or exclude tolerance to an alternative drug.
References
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Journal ArticleDOI
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Munir Pirmohamed,Sally James,Shaun Meakin,Chris D. Green,A Scott,Tom Walley,Keith Farrar,B. Kevin Park,Alasdair Breckenridge +8 more
TL;DR: The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.
Journal ArticleDOI
A new system for grading recommendations in evidence based guidelines
Robin Harbour,Juliet Miller +1 more
TL;DR: A revised system of determining levels of evidence and grades for guideline recommendations is published, based on the work of the US Agency for Healthcare Research and Quality and its applicability to the target population of the guideline.
Journal ArticleDOI
Intolerance to Aspirin: Clinical Studies and Consideration of its Pathogenesis
Max Samter,Ray F. Beers +1 more
Journal ArticleDOI
Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.
Werner Aberer,Andreas J. Bircher,Antonino Romano,Miguel Blanca,Paolo Campi,Javier Fernández,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself.
Journal ArticleDOI
Delayed Drug Hypersensitivity Reactions
TL;DR: This review presents newer concepts of the role of T cells in drug hypersensitivity, which evolved from the study of drug-specific T Cells in various drug-induced hypersensitivity diseases.
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