Journal ArticleDOI
Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs
Marek L. Kowalski,Riccardo Asero,Sevim Bavbek,Miguel Blanca,Natalia Blanca-López,Grazyna Bochenek,Knut Brockow,Paloma Campo,Gülfem Çelik,Josefina Cernadas,G Cortellini,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Andrzej Szczeklik,S. Testi,María José Torres,Stefan Wöhrl,Joanna Makowska +18 more
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TLDR
This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs.Abstract:
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ manifestations, and severity, involving either immunological (allergic) or nonimmunological mechanisms. Proper classification of reactions based on clinical manifestations and suspected mechanism is a prerequisite for the implementation of rational diagnostic procedures and adequate patient management. This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs. The document proposes also practical algorithms for the diagnosis of specific types of NSAIDs hypersensitivity (which include drug provocations, skin testing and in vitro testing) and provides, when data are available, evidence-based recommendations for the management of hypersensitive patients, including drug avoidance and drug desensitization.read more
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International Consensus Statement on Allergy and Rhinology: Rhinosinusitis.
Richard R. Orlandi,Todd T. Kingdom,Peter H. Hwang,Tim Smith,Jeremiah A. Alt,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Neil Bhattacharyya,Rakesh K. Chandra,Alexander G. Chiu,Martin J. Citardi,Noam A. Cohen,John M. DelGaudio,Martin Desrosiers,Hun Jong Dhong,Richard G. Douglas,Berrylin J. Ferguson,Wytske Fokkens,Christos Georgalas,Andrew N. Goldberg,Jan Gosepath,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Claire Hopkins,Roger Jankowski,Amin R. Javer,Robert C. Kern,Stilianos E. Kountakis,Marek L. Kowalski,Andrew P. Lane,Donald C. Lanza,Richard A. Lebowitz,Heung Man Lee,Sandra Y. Lin,Valerie J. Lund,Amber U Luong,Wolf Mann,Bradley F. Marple,Kevin C. McMains,Ralph Metson,Robert M. Naclerio,Jayakar V. Nayak,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Anju T. Peters,Jay F. Piccirillo,David M. Poetker,Alkis J. Psaltis,Hassan H. Ramadan,Vijay R. Ramakrishnan,Herbert Riechelmann,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Brent A. Senior,Raj Sindwani,James A. Stankiewicz,Michael G. Stewart,Bruce K. Tan,Elina Toskala,Richard Louis Voegels,De Yun Wang,Erik K. Weitzel,Sarah K. Wise,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Bing Zhou,David W. Kennedy +74 more
TL;DR: This dissertation aims to provide a history of Chinese medical practice in the United States from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “modern China” began to circulate.
Journal ArticleDOI
Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology
Graham Roberts,M. Xatzipsalti,Luís Miguel Borrego,Adnan Custovic,Susanne Halken,P. W. Hellings,Nikolaos G. Papadopoulos,G. Rotiroti,Glenis Scadding,Frans Timmermans,Erkka Valovirta +10 more
TL;DR: Oral and intranasal antihistamines and nasal corticosteroids are both appropriate for first‐line AR treatment although the latter are more effective, and potentially useful add‐on therapies for AR include oral leukotriene receptor antagonists, short bursts of a nasal decongestant, saline douches and nasal anticholinergics.
Journal ArticleDOI
Anaesthesia, surgery, and life-threatening allergic reactions: epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6)
Nigel J.N. Harper,Nigel J.N. Harper,Tim Cook,Tim Cook,Tim Cook,Tomaz Garcez,L. Farmer,K. Floss,S. Marinho,H. Torevell,A. Warner,K. Ferguson,J. Hitchman,W. Egner,W. Egner,Harriet I. Kemp,M. Thomas,D.N. Lucas,S. Nasser,S. Karanam,K.-L. Kong,S. Farooque,M. Bellamy,M. Bellamy,N. McGuire +24 more
TL;DR: The overall incidence of perioperative anaphylaxis was estimated to be 1 in 10 000 anaesthetics, and poor outcomes were associated with increased ASA, obesity, beta blocker, and angiotensin‐converting enzyme inhibitor medication.
Journal ArticleDOI
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Marek L. Kowalski,Ioana Agache,Sevim Bavbek,Arzu Bakirtas,Miguel Blanca,Grazyna Bochenek,Matteo Bonini,Enrico Heffler,Ludger Klimek,Tanya M. Laidlaw,Joaquim Mullol,Ewa Nizankowska-Mogilnicka,Hae-Sim Park,Marek Sanak,Mario Sánchez-Borges,Silvia Sanchez-Garcia,Glenis Scadding,Masami Taniguchi,María José Torres,Andrew A. White,Aleksandra Wardzyńska +20 more
TL;DR: Recommendations for the most effective management of a patient with N‐ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed.
Journal ArticleDOI
In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper
Cristobalina Mayorga,Gülfem Çelik,Paul Rouzaire,Paul Whitaker,Patrizia Bonadonna,J Rodrigues-Cernadas,Alessandra Vultaggio,Knut Brockow,Jean-Christoph Roger J-P Caubet,Joanna Makowska,Alla Nakonechna,A. Romano,Maria I. Montañez,Jose Julio Laguna,G Zanoni,Jean-Louis Guéant,H. N. G. Oude Elberink,Javier Fernández,Sébastien Viel,Pascal Demoly,María José Torres +20 more
TL;DR: A task force to provide data and recommendations regarding the available in vitro methods for DHR diagnosis has found that although there are many in vitro tests, few can be given a recommendation of grade B or above mainly because of a lack of well‐controlled studies.
References
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Ibuprofen-induced acute generalized exanthematous pustulosis.
TL;DR: Acute generalized exanthematous pustulosis is a rare condition characterized by an acute pustular eruption involving most of the body, usually precipitated by drugs, and it can occur after the use of a variety of medications.
Journal Article
Aspirin challenge/desensitisation before coronary stenting in subjects with history of hypersensitivity. A pragmatic approach.
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Journal ArticleDOI
Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Nami Shrestha Palikhe,Seung-Hyun Kim,Hyun Jung Jin,Eui-Kyung Hwang,Young-Hee Nam,Hae-Sim Park +5 more
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Journal ArticleDOI
Safe Administration of Celecoxib to a Patient with Repeated Episodes of Nephrotic Syndrome Induced by NSAIDs
TL;DR: Challenge with a structurally distinct NSAID (such as celecoxib in this case) may be an option, under close surveillance, in a patient with a history of nephrotic syndrome associated with use of an NSAID when continued treatment with anNSAID is indicated.
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