Journal ArticleDOI
Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs
Marek L. Kowalski,Riccardo Asero,Sevim Bavbek,Miguel Blanca,Natalia Blanca-López,Grazyna Bochenek,Knut Brockow,Paloma Campo,Gülfem Çelik,Josefina Cernadas,G Cortellini,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Andrzej Szczeklik,S. Testi,María José Torres,Stefan Wöhrl,Joanna Makowska +18 more
Reads0
Chats0
TLDR
This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs.Abstract:
Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti-inflammatory drugs (NSAIDs) constitute only a subset of all adverse reactions to these drugs, but due to their severity pose a significant burden to patients and are a challenge to the allergist. In susceptible individuals, NSAIDs induce a wide spectrum of hypersensitivity reactions with various timing, organ manifestations, and severity, involving either immunological (allergic) or nonimmunological mechanisms. Proper classification of reactions based on clinical manifestations and suspected mechanism is a prerequisite for the implementation of rational diagnostic procedures and adequate patient management. This document, prepared by a panel of experts from the European Academy of Allergy and Clinical Immunology Task Force on NSAIDs Hypersensitivity, aims at reviewing the current knowledge in the field and proposes uniform definitions and clinically useful classification of hypersensitivity reactions to NSAIDs. The document proposes also practical algorithms for the diagnosis of specific types of NSAIDs hypersensitivity (which include drug provocations, skin testing and in vitro testing) and provides, when data are available, evidence-based recommendations for the management of hypersensitive patients, including drug avoidance and drug desensitization.read more
Citations
More filters
Journal ArticleDOI
Intérêt des tests cutanés allergologiques dans les hypersensibilités aux AINS
TL;DR: Etude retrospective, monocentrique, d’un AINS appartenant a la meme famille que l’AINS en cause etaient bien supportees ce qui suggere qu’il n’y a pas d”allergie croisee obligatoire intra-classe”.
Journal ArticleDOI
Lack of Major Involvement of Common CYP2C Gene Polymorphisms in the Risk of Developing Cross-Hypersensitivity to NSAIDs.
Yolanda Macías,J M García-Menaya,Manuel Martí,Concepción Cordobés,Raquel Jurado-Escobar,Jose A. Cornejo-Garcia,María José Torres,Natalia Blanca-López,Gabriela Canto,Miguel Blanca,Jose Julio Laguna,Joan Bartra,A. Rosado,Javier Fernández,Elena García-Martín,José A. G. Agúndez +15 more
TL;DR: In this article, the authors analyzed common functional gene variants for CYP2C8, CYP 2C9, and C19 in a large cohort composed of 499 patients with cross-hypersensitivity to non-steroidal anti-inflammatory drugs and 624 healthy individuals who tolerated NSAIDs.
Journal ArticleDOI
Genetic Variants Associated With Drug-Induced Hypersensitivity Reactions: towards Precision Medicine?
Inmaculada Doña,Raquel Jurado-Escobar,Natalia Pérez-Sánchez,Jose Julio Laguna,Joan Bartra,Joan Bartra,Almudena Testera-Montes,Rocío Sáenz de Santa María,María José Torres,Jose A. Cornejo-Garcia +9 more
TL;DR: In this article, the authors summarize current data on the genetics of drug hypersensitivity reactions and include information concerning pharmacogenomic testing and new available technological approaches that could be applied for their study.
Journal ArticleDOI
English version: personalized desensitization with acetylsalicylic acid in patients with hypersensitivity to non-steroidal anti-inflammatory drugs
TL;DR: Desensitization followed by long-term aspirin therapy is an effective method of treating hypersensitivity to aspirin or other NSAIDs and can significantly alleviate the symptoms of asthma, allergic rhinitis.
Peer Review
Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review et al . Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review. Allergy 2016,
Abderrahim Oussalah,Cristobalina Mayorga,Miguel Blanca,Annick Barbaud,Alla Nakonechna,Josefina Cernadas,M. Gotua,Knut Brockow,Jean-Christoph Roger J-P Caubet,A. J. Bircher,M. Atanaskovic,Pascal Demoly,Lucianna Tanno,-. I.Terree,Horst,Jose Julio Laguna,Antonino Romano +16 more
TL;DR: A systematic review of genetic predictors of IgE-mediated AR and NAR with MEDLINE and PubMed search engine highlights the lack of reliable data and the need for replicating studies in contrasted populations, taking into account worldwide allele frequencies, gene – gene interactions, and contrasted situations of environmental exposure.
References
More filters
Journal ArticleDOI
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
Munir Pirmohamed,Sally James,Shaun Meakin,Chris D. Green,A Scott,Tom Walley,Keith Farrar,B. Kevin Park,Alasdair Breckenridge +8 more
TL;DR: The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.
Journal ArticleDOI
A new system for grading recommendations in evidence based guidelines
Robin Harbour,Juliet Miller +1 more
TL;DR: A revised system of determining levels of evidence and grades for guideline recommendations is published, based on the work of the US Agency for Healthcare Research and Quality and its applicability to the target population of the guideline.
Journal ArticleDOI
Intolerance to Aspirin: Clinical Studies and Consideration of its Pathogenesis
Max Samter,Ray F. Beers +1 more
Journal ArticleDOI
Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations.
Werner Aberer,Andreas J. Bircher,Antonino Romano,Miguel Blanca,Paolo Campi,Javier Fernández,Knut Brockow,Werner J. Pichler,Pascal Demoly +8 more
TL;DR: A drug provocation test (DPT) is the controlled administration of a drug in order to diagnose drug hypersensitivity reactions under medical surveillance, whether this drug is an alternative compound, or structurally/pharmacologically related, or the suspected drug itself.
Journal ArticleDOI
Delayed Drug Hypersensitivity Reactions
TL;DR: This review presents newer concepts of the role of T cells in drug hypersensitivity, which evolved from the study of drug-specific T Cells in various drug-induced hypersensitivity diseases.
Related Papers (5)
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA(#) and GA2LEN/HANNA*.
Marek L. Kowalski,Joanna Makowska,Miguel Blanca,Sevim Bavbek,Grazyna Bochenek,Jean Bousquet,Philippe-Jean Bousquet,Gülfem Çelik,Pascal Demoly,Eva Rebelo Gomes,Ewa Nizankowska-Mogilnicka,Antonino Romano,Mario Sánchez-Borges,Maria L. Sanz,María José Torres,A.L. de Weck,Andrzej Szczeklik,Knut Brockow +17 more
Skin test concentrations for systemically administered drugs -- an ENDA/EAACI Drug Allergy Interest Group position paper
Knut Brockow,Lh Garvey,Werner Aberer,Marina Atanaskovic-Markovic,A. Barbaud,M. B. Bilò,Andreas J. Bircher,Miguel Blanca,B Bonadonna,Paolo Campi,E Castro,Jr Cernadas,Am Chiriac,Pascal Demoly,Martine Grosber,J Gooi,Carla Lombardo,Pm Mertes,Holger Mosbech,S Nasser,M. Pagani,J. Ring,Audrey Romano,Kathrin Scherer,B Schnyder,S. Testi,María José Torres,Axel Trautmann,Ingrid Terreehorst +28 more