Journal ArticleDOI
Clenbuterol and anabolic steroids: a previously unreported cause of myocardial infarction with normal coronary arteriograms.
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TLDR
A case of myocardial infarction in an otherwise healthy 26-year-old body-builder who recently used clenbuterol and anabolic steroids is reported, and synergistic effects of the two agents seem likely to have played a role in the infarct.Abstract:
During the last 10 years, several cases of myocardial infarction associated with anabolic steroid use have been reported. Postulated mechanisms to explain this association have included changes in lipid levels, the fibrinolytic system, and platelet aggregation. Clenbuterol is a beta 2-agonist with anabolic properties that has not been seen previously with myocardial infarction. We report a case of myocardial infarction in an otherwise healthy 26-year-old body-builder who recently used clenbuterol and anabolic steroids. In this case, synergistic effects of the two agents seem likely to have played a role in the infarct. The normal coronary arteriograms before any anticoagulant or thrombolytic therapy strongly suggest coronary spasm as the mechanism of the infarct.read more
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Journal ArticleDOI
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Gordon S. Lynch,James G. Ryall +1 more
TL;DR: The physiological significance ofbeta-adrenergic signaling in skeletal muscle is described and the proposed beneficial effects of beta-agonist administration on skeletal muscle along with some of the less desirable cardiovascular effects are examined.
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The potential and the pitfalls of beta-adrenoceptor agonists for the management of skeletal muscle wasting.
James G. Ryall,Gordon S. Lynch +1 more
TL;DR: The therapeutic potential of stimulating the beta-adrenergic signaling pathway with beta-agonists is described, highlighting the beneficial effects on skeletal muscle structure and function and identifying some of the pitfalls associated with short- and long-term beta-agonist administration.
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‘Body Image’ Drugs: A Growing Psychosomatic Problem
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Myotoxic effects of clenbuterol in the rat heart and soleus muscle
TL;DR: Data show significant myocyte-specific necrosis in the heart and skeletal muscle of the rat, which suggests that clenbuterol may be damaging to long-term health.
Journal ArticleDOI
Acute clenbuterol overdose resulting in supraventricular tachycardia and atrial fibrillation.
TL;DR: A body builder using veterinary clenbuterol developed significant electrolyte and cardiac manifestations and was discharged with oral metoprolol, and the patient’s urine was negative for any drugs of abuse.