Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection.
Sang Min Oh,Hyeonju Jeong,Euijin Chang,Pyoeng Gyun Choe,Chang Kyung Kang,Wan Beom Park,Taek Soo Kim,Woon Yong Kwon,Myoung Don Oh,Nam Joong Kim +9 more
TLDR
In this paper, the authors evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 compared to the reverse transcription-polymerase chain reaction (RT-PCR) test.Abstract:
We evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 (COVID-19) compared to the reverse transcription-polymerase chain reaction (RT-PCR) test. We applied both tests to patients who were about to be hospitalized, had visited an emergency room, or had been admitted due to COVID-19 confirmed by RT-PCR. Two nasopharyngeal swabs were obtained; one was tested by RT-PCR and the other by the Standard Q COVID-19 Ag test. A total of 118 pairs of tests from 98 patients were performed between January 5 and 11, 2021. The overall sensitivity and specificity for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for the Standard Q COVID-19 Ag test compared to RT-PCR were 17.5% (95% confidence interval [CI], 8.8-32.0%) and 100% (95% CI, 95.3-100.0%). Analysis of the results using RT-PCR cycle thresholds of ≤ 30 or ≤ 25 increased the sensitivity to 26.9% (95% CI, 13.7-46.1%), and 41.1% (95% CI, 21.6-64.0%), respectively.read more
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Accuracy of novel antigen rapid diagnostics for SARS-CoV-2: A living systematic review and meta-analysis.
Lukas E. Brümmer,Stephan Katzenschlager,Mary Gaeddert,Christian Erdmann,Stephani Schmitz,Marc Bota,Maurizio Grilli,Jan Larmann,Markus A. Weigand,Nira R. Pollock,Aurélien Macé,Sergio Carmona,Stefano Ongarello,Jilian A. Sacks,Claudia M. Denkinger,Claudia M. Denkinger +15 more
TL;DR: A systematic review and meta-analysis of commercially available rapid diagnostic tests (Ag-RDTs) for SARS-CoV-2 up until 30 April 2021 was conducted in this paper.
Posted ContentDOI
The accuracy of novel antigen rapid diagnostics for SARS-CoV-2: a living systematic review and meta-analysis.
Lukas E. Brümmer,Stephan Katzenschlager,Mary Gaeddert,Christian Erdmann,Stephani Schmitz,Marc Bota,Maurizio Grilli,Jan Larmann,Markus A. Weigand,Nira R. Pollock,Sergio Carmona,Stefano Ongarello,Jilian A. Sacks,Claudia M. Denkinger +13 more
TL;DR: In this article, a systematic review and meta-analysis of commercially available rapid diagnostic tests (Ag-RDTs) is presented, where the clinical accuracy (sensitivity and specificity) of these tests are assessed.
Journal ArticleDOI
Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection
TL;DR: In this article , the second update of this review was published, which was first published in 2020, and included 152 evaluations of single test applications including 100,462 unique samples (16,822 with confirmed SARS-CoV-2 infection or known absence of infection).
Journal ArticleDOI
Diagnostic usefulness of subgenomic RNA detection of viable SARS-CoV-2 in patients with COVID-19.
Ji Yeun Kim,Joon-Yong Bae,Seongman Bae,Hye Hee Cha,Ji-Soo Kwon,Mi Hyun Suh,Hyun Jung Lee,Jiwon Jung,Min Jae Kim,Chunguang Cui,Heedo Park,Jungmin Lee,Man-Seong Park,Sung-Han Kim +13 more
TL;DR: In this paper, the authors evaluated the usefulness of subgenomic RNAs for diagnosing viable SARS-CoV-2 in patients with COVID-19 in patients at a tertiary hospital between February and December 2020.
Journal ArticleDOI
Diagnostic usefulness of subgenomic RNA detection of viable SARS-CoV-2 in patients with COVID-19
TL;DR: In this paper , the authors evaluated the usefulness of subgenomic RNAs for diagnosing viable SARS-CoV-2 in patients with COVID-19 in patients enrolled at a tertiary hospital between February and December 2020.
References
More filters
Journal ArticleDOI
Rethinking Covid-19 Test Sensitivity - A Strategy for Containment.
TL;DR: A simple point-of-care test that is inexpensive enough to use frequently, even if it lacks sensitivity, is proposed for Covid-19 cases.
Journal ArticleDOI
Field evaluation of a rapid antigen test (Panbio™ COVID-19 Ag Rapid Test Device) for COVID-19 diagnosis in primary healthcare centres.
Eliseo Albert,Ignacio Torres,Felipe Bueno,Dixie Huntley,Estefanía Molla,Miguel Ángel Fernández-Fuentes,Mireia Martínez,Sandrine Poujois,Lorena Forqué,Arantxa Valdivia,Carlos Solano de la Asunción,Josep Ferrer,Javier Colomina,David Navarro +13 more
TL;DR: The data suggested that patients with RT-PCR-proven COVID-19 testing negative by RAD are unlikely to be infectious, and the Panbio™ CO VID-19 Ag Rapid Test Device performed well as a POCT for early diagnosis in primary healthcare centers.
Journal ArticleDOI
Performance of an Antigen-Based Test for Asymptomatic and Symptomatic SARS-CoV-2 Testing at Two University Campuses - Wisconsin, September-October 2020.
Ian W Pray,Laura Ford,Devlin Cole,Christine M. Lee,John Paul Bigouette,Glen R. Abedi,Dena Bushman,Miranda J Delahoy,Dustin W Currie,Blake Cherney,Marie K. Kirby,Geroncio C Fajardo,Motria Caudill,Kimberly Langolf,Juliana Kahrs,Patrick Kelly,Collin Pitts,Ailam Lim,Nicole A. Aulik,Azaibi Tamin,Jennifer L Harcourt,Krista Queen,Jing Zhang,Brett Whitaker,Hannah Browne,Magdalena Medrzycki,Patricia L. Shewmaker,Jennifer M Folster,Bettina Bankamp,Michael D. Bowen,Natalie J. Thornburg,Kimberly Goffard,Brandi Limbago,Allen C. Bateman,Jacqueline E. Tate,Douglas Gieryn,Hannah L Kirking,Ryan P. Westergaard,Marie E Killerby +38 more
TL;DR: In this paper, the Sofia SARS Antigen Fluorescent Immunoassay (FIA) was compared with real-time reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 detection among asymptomatic and symptomatic persons at two universities in Wisconsin.
Journal ArticleDOI
Head-to-head comparison of SARS-CoV-2 antigen-detecting rapid test with self-collected nasal swab versus professional-collected nasopharyngeal swab.
Andreas K. Lindner,Olga Nikolai,Franka Kausch,Mia Wintel,Franziska Hommes,Maximilian Gertler,Lisa J. Krüger,Mary Gaeddert,Frank Tobian,Federica Lainati,Lisa Köppel,Joachim Seybold,Victor M. Corman,Christian Drosten,Jörg Hofmann,Jilian A. Sacks,Frank P. Mockenhaupt,Claudia M. Denkinger +17 more
TL;DR: Supervised nasal self-sampling is a reliable alternative to professional nasopharyngeal sampling using a WHO-listed SARS-CoV-2 antigen-detecting rapid test and potentially patient self-testing may be a future use case.
Journal ArticleDOI
Comparison of Rapid Antigen Tests for COVID-19.
Seiya Yamayoshi,Yuko Sakai-Tagawa,Michiko Koga,Osamu Akasaka,Ichiro Nakachi,Hidefumi Koh,Kenji Maeda,Eisuke Adachi,Makoto Saito,Hiroyuki Nagai,Kazuhiko Ikeuchi,Takayuki Ogura,Rie Baba,Kensuke Fujita,Takahiro Fukui,Fumimaro Ito,Shin ichiro Hattori,Kei Yamamoto,Takato Nakamoto,Yuri Furusawa,Atsuhiro Yasuhara,Michiko Ujie,Shinya Yamada,Mutsumi Ito,Hiroaki Mitsuya,Norio Omagari,Hiroshi Yotsuyanagi,Kiyoko Iwatsuki-Horimoto,Masaki Imai,Yoshihiro Kawaoka,Yoshihiro Kawaoka +30 more
TL;DR: Although the current RATs will likely miss some COVID-19 patients who are shedding infectious SARS-CoV-2 patients, even the most sensitive RAT read the samples containing small amounts of virus as negative, and all R ATs tested failed to detect viral antigens in several specimens from which the virus was isolated.