Journal ArticleDOI
Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis.
TLDR
The extent of lesions according to the rule of nines showed interobserver variability mostly for patients with lesions of moderate intensity involving 20-60% of body surface, but variations subsided especially for oozing/crusts and lichenifications.Abstract:
Background: We have previously reported how the SCORAD index was designed. This cumulative index combines objective (extent and intensity of lesions) and subjective (daytime prurituread more
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Journal ArticleDOI
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis
Heidi H. Kong,Julia Oh,Clay Deming,Sean Conlan,Elizabeth A. Grice,Melony A. Beatson,Effie Y.H. Nomicos,Eric C. Polley,Hirsh D. Komarow,Nisc Comparative Sequence Program,Patrick R. Murray,Maria L. Turner,Julia A. Segre +12 more
TL;DR: Findings reveal linkages between microbial communities and inflammatory diseases such as AD, and demonstrate that as compared with culture-based studies, higher resolution examination of microbiota associated with human disease provides novel insights into global shifts of bacteria relevant to disease progression and treatment.
Journal ArticleDOI
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
Lisa A. Beck,Diamant Thaçi,Jennifer D. Hamilton,Neil M.H. Graham,Thomas Bieber,Ross E. Rocklin,Jeffrey Ming,Haobo Ren,Richard Kao,Eric L. Simpson,Marius Ardeleanu,Steven P. Weinstein,Gianluca Pirozzi,Emma Guttman-Yassky,Mayte Suárez-Fariñas,Melissa D. Hager,Neil Stahl,George D. Yancopoulos,Allen Radin +18 more
TL;DR: Patients treated with dupilumab had marked and rapid improvement in all the evaluated measures of atopic dermatitis disease activity, and side-effect profiles were not dose-limiting.
Journal ArticleDOI
Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I.
Andreas Wollenberg,Sébastien Barbarot,T. Bieber,Stéphanie Christen-Zaech,M. Deleuran,A. Fink-Wagner,U. Gieler,Giampiero Girolomoni,S. Lau,Antonella Muraro,Magdalena Czarnecka-Operacz,Torsten Schäfer,Peter Schmid-Grendelmeier,Dagmar Simon,Zsuzsanna Szalai,Jacek C Szepietowski,Alain Taieb,Antonio Torrelo,Thomas Werfel,J. Ring +19 more
TL;DR: This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients, and is a consensus‐based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account.
Journal ArticleDOI
Guidelines for treatment of atopic eczema (atopic dermatitis) part I.
Johannes Ring,Agustín Alomar,T. Bieber,Mette Deleuran,A. Fink-Wagner,Carlo Gelmetti,U. Gieler,Jasna Lipozenčić,T. A. Luger,Arnold P. Oranje,Torsten Schäfer,T. Schwennesen,Stefania Seidenari,Dagmar Simon,Sonja Ständer,Georg Stingl,S. Szalai,Jacek C Szepietowski,Alain Taïeb,Thomas Werfel,Andreas Wollenberg,Ulf Darsow +21 more
TL;DR: The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation as discussed by the authors.
Journal ArticleDOI
A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age
TL;DR: Results show for the first time a beneficial effect of prebiotics on the development of atopic dermatitis in a high risk population of infants and it appears likely that oligosaccharides modulate postnatal immune development by altering bowel flora and have a potential role in primary allergy prevention during infancy.
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