Journal ArticleDOI
CO2-laser micromachining and back-end processing for rapid production of PMMA-based microfluidic systems
TLDR
Several bonding methods for microstructured PMMA [poly(methyl methacrylate)] parts were investigated, such as solvent-assisted glueing, melting, laminating and surface activation using a plasma asher.Abstract:
In this article, we focus on the enormous potential of a CO2-laser system for rapidly producing polymer microfluidic structures. The dependence was assessed of the depth and width of laser-cut channels on the laser beam power and on the number of passes of the beam along the same channel. In the experiments the laser beam power was varied between 0 and 40 W and the passes were varied in the range of 1 to 7 times. Typical channel depths were between 100 and 300 μm, while the channels were typically 250 μm wide. The narrowest produced channel was 85 μm wide. Several bonding methods for microstructured PMMA [poly(methyl methacrylate)] parts were investigated, such as solvent-assisted glueing, melting, laminating and surface activation using a plasma asher. A solvent-assisted thermal bonding method proved to be the most time-efficient one. Using laser micromachining together with bonding, a three-layer polymer microstructure with included optical fibers was fabricated within two days. The use of CO2-laser systems to produce microfluidic systems has not been published before. These systems provide a cost effective alternative to UV-laser systems and they are especially useful in microfluidic prototyping due to the very short cycle time of production.read more
Citations
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Point of care diagnostics: Status and future
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Micro total analysis systems. Recent developments.
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Polymer microfabrication technologies for microfluidic systems
Holger Becker,Claudia Gärtner +1 more
TL;DR: This review will introduce the currently relevant microfabrication technologies such as replication methods like hot embossing, injection molding, microthermoforming and casting as well as photodefining methods like lithography and laser ablation for microfluidic systems and discuss academic and industrial considerations for their use.
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Engineers are from PDMS-land, Biologists are from Polystyrenia
TL;DR: A critical evaluation of the strengths and limitations of PDMS and PS in relation to the advancement and future impact on microfluidic cell-based studies and applications is provided and guidelines for researchers who desire to choose the most suitable material for their application are provided.
References
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Journal ArticleDOI
Polymer microfluidic devices
Holger Becker,Laurie E. Locascio +1 more
TL;DR: This article presents a review of polymer-based microfluidic systems including their material properties, fabrication methods, device applications, and finally an analysis of the market that drives their development.
Journal ArticleDOI
The berthelot or indophenol reaction and its use in the analytical chemistry of nitrogen. A review
Journal ArticleDOI
Microchannel electrophoretic separations of DNA in injection-molded plastic substrates
TL;DR: These devices could lead to the production of low-cost, single-use electrophoretic chips suitable for a variety of separation applications, including DNA sizing, DNA sequencing, random primary library screening, and rapid immunoassay testing.
Journal ArticleDOI
Fabrication of plastic microfluid channels by imprinting methods.
Larissa E. Martynova,Laurie E. Locascio,Michael Gaitan,Gary W. Kramer,Richard G. Christensen,William A. MacCrehan +5 more
TL;DR: Microfluidic devices have been fabricated on poly(methyl methacrylate) substrates by two independent imprinting techniques and fluorescent analtyes were used to demonstrate reproducible electrophoretic injections.
Journal ArticleDOI
UV Laser Machined Polymer Substrates for the Development of Microdiagnostic Systems
TL;DR: In this paper, a UV laser photoablation method for the production of miniaturized liquid-handling systems on polymer substrate chips was described. But the method was used for producing channels in polystyrene, polycarbonate, cellulose acetate, and poly(ethylene terephthalate).
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