Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Yifeng Zhang,Mark A. Hoon,Jayaram Chandrashekar,Ken Mueller,Boaz Cook,Dianqing Wu,Charles S. Zuker,Nicholas J. P. Ryba +7 more
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TLDR
It is demonstrated that knockouts of TRPM5, a taste TRP ion channel, or PLCbeta2, a phospholipase C selectively expressed in taste tissue, abolish sweet, amino acid, and bitter taste reception, but do not impact sour or salty tastes.About:
This article is published in Cell.The article was published on 2003-02-07 and is currently open access. It has received 1172 citations till now. The article focuses on the topics: TRPM5 & TAS2R38.read more
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TRP channels as cellular sensors
TL;DR: TRP channels are the vanguard of the authors' sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli, but their role is much broader than classical sensory transduction.
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An Introduction to TRP Channels
TL;DR: The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems.
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The receptors and cells for mammalian taste
TL;DR: The emerging picture of taste coding at the periphery is one of elegant simplicity, it is now clear that distinct cell types expressing unique receptors are tuned to detect each of the five basic tastes.
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Transient Receptor Potential Cation Channels in Disease
TL;DR: An overview of the impact of TRP channels on the pathogenesis of several diseases is provided and several TRPs for which a causal pathogenic role might be anticipated are identified.
Journal ArticleDOI
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
TL;DR: This review is an attempt to give an overview of this enormous research field focusing on major developments in diverse areas of basic science linked to cellular physiology and disease.
References
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Mammalian sweet taste receptors
Charles S. Zuker,Nicholas J. P. Ryba,Gregory A. Nelson,Mark A. Hoon,Jayaram Chandrashekar,Yifeng Zhang +5 more
TL;DR: A detailed analysis of the patterns of expression of T1Rs and T2Rs is presented, thus providing a view of the representation of sweet and bitter taste at the periphery.
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An amino-acid taste receptor
Greg Nelson,Jayaram Chandrashekar,Mark A. Hoon,Luxin Feng,Grace Zhao,Nicholas J. P. Ryba,Charles S. Zuker +6 more
TL;DR: This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.
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Human receptors for sweet and umami taste
TL;DR: It is shown that human T1R2/T1R3 recognizes diverse natural and synthetic sweeteners, and this response is enhanced by 5′-ribonucleotides, a hallmark of umami taste, which implicate the T1Rs inUmami taste and suggest that sweet and Umami taste receptors share a common subunit.
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T2Rs function as bitter taste receptors.
Jayaram Chandrashekar,Ken Mueller,Mark A. Hoon,Elliot Adler,Luxin Feng,Wei Guo,Charles S. Zuker,Nicholas J. P. Ryba +7 more
TL;DR: A heterologous expression system is used to show that specific T2Rs function as bitter taste receptors, and these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds.
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A novel family of mammalian taste receptors.
Elliot Adler,Mark A. Hoon,Ken Mueller,Jayaram Chandrashekar,Nicholas J. P. Ryba,Charles S. Zuker +5 more
TL;DR: It is demonstrated that T2Rs couple to gustducin in vitro, and respond to bitter tastants in a functional expression assay, implying that they function as gust Ducin-linked receptors.