Cognitive and motor correlates of grey and white matter pathology in Parkinson's disease.
TLDR
Both grey and white matter damage contribute to motor and cognitive deficits in PD and the relationships between MRI measurements and clinical symptoms in PD are assessed.About:
This article is published in NeuroImage: Clinical.The article was published on 2020-01-01 and is currently open access. It has received 35 citations till now. The article focuses on the topics: Hyperintensity & White matter.read more
Citations
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The contribution of white matter lesions (WML) to Parkinson'sdisease cognitive impairment symptoms: A critical review of theliterature
Branislav Veselý,Ivan Rektor +1 more
TL;DR: In this paper, the impact of white matter lesions (WML) on cognitive impairment in Parkinson's disease patients was reviewed and the negative impact of WML on cognition was described.
Journal ArticleDOI
Beware of white matter hyperintensities causing systematic errors in FreeSurfer gray matter segmentations
TL;DR: This paper investigated the impact of the presence of white matter hyperintensities (WMHs) on FreeSurfer gray matter (GM) structure volumes and its possible bias on functional relationships.
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Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein–induced changes in maturation and immune reactive properties
Carla Azevedo,Gabriel N. Teku,Yuriy Pomeshchik,Juan F. Reyes,Margarita Chumarina,Kaspar Russ,Ekaterina Savchenko,Anna Hammarberg,Nuno Jorge Lamas,Anna Collin,Gunnar K. Gouras,Oxana Klementieva,Martin Hallbeck,Ricardo Taipa,Mauno Vihinen,Laurent Roybon +15 more
TL;DR: The results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in Parkinson’s disease and multiple system atrophy and reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multipleSystem atrophy.
Journal ArticleDOI
The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease.
Hailing Liu,Bin Deng,Fen Xie,Xiaohua Yang,Zhenchao Xie,Yonghua Chen,Zhi Yang,Xiyan Huang,Shuzhen Zhu,Qing Wang +9 more
TL;DR: In this article, a meta-analysis was conducted to identify the relationship between the severity and location of white matter hyperintensities (WMHs) and the degree of cognitive decline in patients with Parkinson's disease.
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White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia
TL;DR: In this paper , the impact of WMHs on grey matter atrophy and cognition in normal aging (n = 571), mild cognitive impairment (MCI, n = 551), Alzheimer's dementia (AD, N = 212), fronto-temporal dementia (FTD, N= 125), and Parkinson's disease (PD, n= 271).
References
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The Clinical Dementia Rating (CDR): Current version and scoring rules
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Voxel-Based Morphometry—The Methods
John Ashburner,Karl J. Friston +1 more
TL;DR: In this paper, the authors describe the steps involved in VBM, with particular emphasis on segmenting gray matter from MR images with non-uniformity artifact and provide evaluations of the assumptions that underpin the method, including the accuracy of the segmentation and the assumptions made about the statistical distribution of the data.
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A nonparametric method for automatic correction of intensity nonuniformity in MRI data
TL;DR: A novel approach to correcting for intensity nonuniformity in magnetic resonance (MR) data is described that achieves high performance without requiring a model of the tissue classes present, and is applied at an early stage in an automated data analysis, before a tissue model is available.
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Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.