Showing papers in "Neurobiology of Aging in 2022"

TL;DR: In this paper , the role of the locus coeruleus (LC), the brain's main noradrenergic supply, was investigated for early onset of Alzheimer's disease in symptomatic individuals.

TL;DR: The Collaboratory on Research Definitions for Reserve and Resilience in Cognitive Aging and Dementia was established in 2019 as a 3-year process of developing consensus definitions and research guidelines as discussed by the authors .

TL;DR: The first longitudinal study of cognitive aging in marmosets was conducted in this paper, where the authors characterized aging trajectories using reversal learning with different stimuli each year, suggesting the onset of age-related decline.

TL;DR: In this article , the authors investigated whether age-related differences in aperiodic activity explains differences in resting EEG peak alpha frequency and power, and found that alpha frequency remained slower in older adults, while peak alpha power no longer differed statistically between age groups.

TL;DR: The first longitudinal study of cognitive aging in marmosets (N = 28) as they transitioned from middle-to old age (∼5 years) to old age was conducted in this paper .

TL;DR: In this paper , the impact of WMHs on grey matter atrophy and cognition in normal aging (n = 571), mild cognitive impairment (MCI, n = 551), Alzheimer's dementia (AD, N = 212), fronto-temporal dementia (FTD, N= 125), and Parkinson's disease (PD, n= 271).

TL;DR: In this article, the authors compared longitudinal trajectories in three motor neuron phenotypes; a UMN-predominant syndrome (PLS), a mixed UMN-, and a lower motor neuron condition (poliomyelitis survivors).

TL;DR: In this paper , the authors summarize evidence and rationale on why and how to target apoE4 reduction for AD therapy and propose a promising therapeutic strategy for the treatment of AD patients carrying the APOE ε4 allele.

TL;DR: The authors examined the characteristics of individuals with biomarker evidence of tauopathy but without β-amyloid (Aβ) (A-T+) in relation to individuals with (A+T+) and without (A-) evidence of Alzheimer's disease (AD).

TL;DR: The authors examined the characteristics of individuals with biomarker evidence of tauopathy but without β-amyloid (Aβ) (A-T+) in relation to individuals with (A+T+) and without (A-) evidence of Alzheimer's disease (AD).

TL;DR: In this article, behavioral and physiological deficits in the PS19 mouse model, a broadly utilized model of tauopathy, were assessed and the correlation between these pathological hallmarks and functional deficits was found.

TL;DR: In this article , behavioral and physiological deficits in the PS19 mouse model, a broadly utilized model of tauopathy, were assessed and the correlation between these pathological hallmarks and functional deficits was found.

TL;DR: In this article , the clinical and neurobiological effects of noninvasive stimulation over these networks in 45 patients (AD and bvFTD) who received either anodal or cathodal stimulation (target network: SN in AD, DMN in bv FTD).

TL;DR: In this paper , the authors compared longitudinal trajectories in three motor neuron phenotypes; a UMN-predominant syndrome (PLS), a mixed UMN-, and a lower motor neuron condition (poliomyelitis survivors).

TL;DR: For instance, this paper found that auditory cortex in older adults is hyperresponsive to sound onsets, but that sustained neural activity in auditory cortex, indexing the processing of a sound pattern, is reduced.

TL;DR: In this paper, the difference between brain age and chronological age (brain-PAD) is associated with cognitive function at baseline and longitudinally, and the results indicate that even in relatively healthy older adults, accelerated brain aging was associated with worse psychomotor speed, but future longitudinal research into changes in brain PAD is needed.

TL;DR: In this paper , the difference between brain age and chronological age (brain-PAD) is associated with cognitive function at baseline and longitudinally, and the results indicate that even in relatively healthy older adults, accelerated brain aging is associated to worse psychomotor speed, but future longitudinal research into changes in brain PAD is needed.

TL;DR: In this paper , the authors showed significant reductions in hippocampal synaptic density in participants with AD, consistent with the early degeneration of entorhinal cortical (ERC) cells that project to hippocampus via the perforant path.

TL;DR: For instance, this paper found that auditory cortex in older adults is hyperresponsive to sound onsets, but that sustained neural activity in auditory cortex, indexing the processing of a sound pattern, is reduced.

TL;DR: In this paper , the authors used magnetic resonance spectroscopy to quantify metabolite deficits in sixty patients with a clinical syndrome associated with frontotemporal lobar degeneration (behavioral variant fronto-temporal dementia, progressive supranuclear palsy, corticobasal syndrome n = 11, primary progressive aphasias n = 12), and 38 age-and sex-matched healthy controls.

TL;DR: In this article , structural and functional changes associated with impaired memory function differentially engage the lateral entorhinal cortex in patients with mild cognitive impairment, consistent with the locus of early disease related pathology.

TL;DR: In this paper , an MRI index capturing Alzheimer's disease-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort.

TL;DR: In this article, an MRI index capturing Alzheimer's disease-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort.

TL;DR: In this paper , the authors used a lesion prediction algorithm to quantify white matter hyperintensities (WMH) as well as resting-state multiecho functional magnetic resonance imaging to characterize restingstate functional connectivity in a cross-sectional sample of healthy older adults.

TL;DR: In this paper , the authors investigated cross-sectional and longitudinal associations between proactive interference and white-matter integrity using diffusion-weighted imaging in an adult life-span sample (25-80 years; Mage = 60.15; 138 female).

TL;DR: In this article , the authors found that human Tau (hTau) present in brain interstitial fluid (ISF) is truncated and comprises at least 10 distinct fragments spanning the entire Tau protein.

TL;DR: For example, the authors found that cognitively unimpaired older adults exhibited lower levels of global cerebrovascular reactivity under both hypocapnia and hypercapnia relative to younger adults.

TL;DR: In this paper, the authors found that human Tau (hTau) present in brain interstitial fluid (ISF) is truncated and comprises at least 10 distinct fragments spanning the entire Tau protein.

TL;DR: In this paper , the authors used linked independent component analysis (FLICA) to examine covariation in gray (GM) and white (WM) matter changes in a group of older adults (n = 50) and employed a novel technique to estimate the brain age delta (difference between chronological and brain age assessed using neuroimaging data).

TL;DR: This paper investigated progression and interrelationships of cerebral small vessel disease (cSVD) markers, including white-matter hyperintensity (WMH), perivascular spaces (PVS), lacunes, and grey-matter (GM) and ventricular volumes.