Cognitive impairment in euthymic major depressive disorder: a meta-analysis
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Citations
Functional connectivity between the thalamus and the primary somatosensory cortex in major depressive disorder: a resting-state fMRI study.
A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression
Brain network functional connectivity and cognitive performance in major depressive disorder.
The effect of bupropion XL and escitalopram on memory and functional outcomes in adults with major depressive disorder: Results from a randomized controlled trial
Cognitive Dysfunction in Major Depressive Disorder: Assessment, Impact, and Management
References
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Quantifying heterogeneity in a meta‐analysis
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
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Frequently Asked Questions (13)
Q2. What are the future works mentioned in the paper "Cognitive impairment in euthymic major depressive disorder: a meta-analysis" ?
Future studies are needed to examine cognitive performance in euthymic MDD patients with a history of melancholic/non-melancholic and psychotic and non-psychotic features. It is clear that further studies of cognition are needed in euthymic and unmedicated MDD patients. Longitudinal studies that are designed to assess cognition in ‘ at-risk ’ and first-episode populations across the age range will be needed to further clarify the precise nature of cognitive deficits in depression.
Q3. What was the effect of I2 values on between-group differences?
Meta-regression analyses were used to estimate the impact of demographic (age, gender) and clinical (number of episodes, age at illness onset, duration of illness, residual depressive symptoms, based on Hamilton Depression Rating Scale) variables on between-group differences.
Q4. What is the reason for the hippocampus alterations in MDD?
It is likely that hippocampus alterations in adult MDD patients are secondary to active stress-related processes and that such alterations might recover in fully remitted patients.
Q5. What are the main characteristics of MDD?
Within the broad and heterogeneous diagnostic spectrum of MDD, persistent cognitive deficits might be important functional markers of some patient groups.
Q6. what is the psychiatric effect of serotonin reuptake inhibitor?
Major depressive disorder in recovery and neuropsychological functioning : effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with major depressive disorder in recovery.
Q7. What was the effect size of the cognitive deficits in euthymic MDD?
In the whole sample, older age of onset was associated with more severe verbal memory deficits (B=0.32, S.E.=0.09, Z=3.77, p=0.0002).
Q8. What is the reason for the heterogeneity in the data?
It is likely that this heterogeneity is due to variance in the proportion of patients with potentially more severe cognitive deficits, for instance, patients with a history of psychosis or melancholic features during active episodes.
Q9. How many studies were included in the meta-analysis?
A total of 27 studies (30 samples) comparing 895 (60.7% female) patients with MDD and 993 (60.1% female) healthy controls were included in the final meta-analysis (Table 1).
Q10. What was the average magnitude of cognitive dysfunction in euthymic MDD patients?
The average magnitude (Cohen’s d) of cognitive dysfunction in euthymic MDD patients was 0.47, indicating nearly 70% overlap of distributions of cognitive performances of MDD patients and healthy controls.
Q11. What is the significance of the effects of the cognitive tests in euthymic MD?
Their findings provide strong evidence for pronounced cognitive deficits in remitted patients who had their first episode of illness late in life (d=0.64, 60% overlap with controls), with the distribution of effect sizes being strikingly homogeneous in this population.
Q12. What is the common definition of euthymia?
Definitions of euthymia varied between studies, with some of them relying solely on cut-off scores on depression scales while others required a minimum temporal duration (e.g. 2 weeks to 6 months) for clinical remission (Table 1).
Q13. What are the main factors that are needed to examine cognitive performance in euthymic?
Future studies are needed to examine cognitive performance in euthymic MDD patients with a history of melancholic/non-melancholic and psychotic and non-psychotic features.