Journal ArticleDOI
Cold Atmospheric Plasma: Charged Species and Their Interactions With Cells and Tissues
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TLDR
The selected physical properties of typical atmospheric plasma sources will be discussed; experiments will be confronted with theoretical considerations, and several biomedical aspects of CAP treatment will be surveyed.Abstract:
Cold atmospheric plasma (CAP) treatment of living tissues becomes a popular topic in modern plasma physics and in medical sciences. The plasma is capable of bacterial inactivation and noninflammatory tissue modification, which makes it an attractive tool for wound healing and the treatment of skin diseases and dental caries. There are still many open issues with regard to the mechanisms of action of the plasma on bacteria and mammalian cells and tissues, both from the biological and the physical perspective. For example, the chemistry of CAP and the exact roles of various plasma constituents in tissue treatment are not yet fully resolved. In this paper, we shall concentrate on the charged species (electrons and ions) in the plasma. The selected physical properties of typical atmospheric plasma sources will be discussed; experiments will be confronted with theoretical considerations, and several biomedical aspects of CAP treatment will be surveyed.read more
Citations
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Plasma medicine: an introductory review
Michael G. Kong,Gmw Gerrit Kroesen,Gregor E. Morfill,Tetyana Nosenko,Tetsuji Shimizu,van J Jan Dijk,Julia L. Zimmermann +6 more
TL;DR: This introductory review on plasma health care is intended to provide the interested reader with a summary of the current status of this emerging field, its scope, and its broad interdisciplinary approach, ranging from plasma physics, chemistry and technology, to microbiology, biochemistry, biophysics, medicine and hygiene.
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The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology
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Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy
Michael Keidar,R Walk,Alexey Shashurin,Priya Srinivasan,Anthony D. Sandler,Santanu Dasgupta,Rajani Ravi,Rafael Guerrero-Preston,Barry Trink +8 more
TL;DR: The development of cold plasma tumour ablation has the potential of shifting the current paradigm of cancer treatment and enabling the transformation ofcancer treatment technologies by utilisation of another state of matter.
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Low temperature atmospheric pressure plasma sources for microbial decontamination
Jörg Ehlbeck,Uta Schnabel,Martin Polak,Jörn Winter,Th. von Woedtke,Ronny Brandenburg,T. von dem Hagen,K.-D. Weltmann +7 more
TL;DR: An introduction and definition of basic terms and procedures are given for plasma as well as for microbicidal issues to consider the interdisciplinary character of this topic.
References
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Journal ArticleDOI
Role of reactive oxygen species (ROS) in apoptosis induction
TL;DR: The role of ROS in the regulation of apoptosis, especially in inflammatory cells, is focused on, with particular attention to mitochondria.
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Low Temperature Plasma-Based Sterilization: Overview and State-of-the-Art
TL;DR: Low temperature, high pressure, non-equilibrium plAsmas are now routinely used in several material processing applications, and in some cases are competing with low pressure plasmas in areas where these have historically been dominant.
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Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms
TL;DR: In this paper, a review of the literature on plasma sterilization is presented, where three basic mechanisms are involved in the plasma inactivation of microorganisms: (a) direct destruction by UV irradiation of the genetic material of micro organisms; (b) erosion of the microorganisms atom by atom, through intrinsic photodesorption by ultraviolet irradiation to form volatile compounds combining atoms intrinsic to the micro organisms.
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Evaluation of the roles of reactive species, heat, and UV radiation in the inactivation of bacterial cells by air plasmas at atmospheric pressure
Mounir Laroussi,F. Leipold +1 more
TL;DR: In this paper, emission spectroscopy and gas detection are used to evaluate important plasma inactivation factors such as UV radiation and reactive species, and it is shown that for non-equilibrium, atmospheric pressure air plasmas, it is the oxygen-based and nitrogen-based reactive species that play the most important role in the inactivation process.
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Nonthermal decontamination of biological media by atmospheric-pressure plasmas: review, analysis, and prospects
TL;DR: A review of various works on the germicidal effects of atmospheric pressure, "cold" plasmas, is presented in this article, where nonequilibrium discharge devices discussed in this review, which have been used in biological applications by various investigators, are the corona discharge, diffuse dielectric-barrier discharge, resistive barrier discharge, and the atmospheric-pressure plasma jet.