Journal ArticleDOI
Role of reactive oxygen species (ROS) in apoptosis induction
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TLDR
The role of ROS in the regulation of apoptosis, especially in inflammatory cells, is focused on, with particular attention to mitochondria.Abstract:
Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.read more
Citations
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Reactive oxygen species in cancer
Geou Yarh Liou,Peter Storz +1 more
TL;DR: The generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize are discussed, but also an outlook on their modulation in therapeutics is provided.
Journal ArticleDOI
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
TL;DR: Treatment with beta carotene, vitamin A, vitamin E, and vitamin E may increase mortality and the potential roles of vitamin C and selenium on mortality need further study.
Journal ArticleDOI
Reactive oxygen species in tumor progression.
TL;DR: The finding that a diet rich in antioxidants or the elimination of ROS by antioxidant compounds prevents the development of certain cancers provided the setting for subsequent investigation of the tumorigenic actions of reactive oxygen species.
Journal ArticleDOI
Reactive Oxygen Species, Aging, and Antioxidative Nutraceuticals.
J. Lee,N. Koo,David B. Min +2 more
TL;DR: Scientists have indicated that antioxidant nutraceuticals supplied from daily diets quench the reactive oxygen species or are required as cofactors for antioxidant enzymes.
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Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
TL;DR: In this paper, the authors provide the best available information on the effect of anti-oxidants on mortality in patients with various diseases, including cancer, heart disease, and stroke.
References
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Journal ArticleDOI
Mitochondria and apoptosis
Douglas R. Green,John C. Reed +1 more
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
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Death receptors: signaling and modulation
Avi Ashkenazi,Vishva M. Dixit +1 more
TL;DR: Apoptosis is a cell suicide mechanism that enables metazoans to control cell number in tissues and to eliminate individual cells that threaten the animal's survival.
Journal ArticleDOI
Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
TL;DR: It is shown that micromolar concentrations of H2O2 can induce the expression and replication of HIV‐1 in a human T cell line and suggests that diverse agents thought to activate NF‐kappa B by distinct intracellular pathways might all act through a common mechanism involving the synthesis of ROI.
Journal Article
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
David A. Bass,J W Parce,Lawrence R. DeChatelet,Pamela Szejda,Michael C. Seeds,Michael J. Thomas +5 more
TL;DR: The data indicate that the DCFH oxidation assay is quantitatively related to the oxidative metabolic burst of PMNL, and they strongly suggest that the reaction is mediated by H2O2 generated by the PMNL.
Journal ArticleDOI
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.
Naoufal Zamzami,Philippe Marchetti,Maria Castedo,Didier Decaudin,Antonio Macho,Tamara Hirsch,Santos A. Susin,Patrice X. Petit,Bernard Mignotte,Guido Kroemer +9 more
TL;DR: Assessment of mitochondrial ROS generation provides an accurate picture of PCD-mediated lymphocyte depletion and indicates alterations of mitochondrial function constitute an important feature of early PCD.