Journal ArticleDOI
Collagen synthesis by monkey arterial smooth muscle cells during proliferation and quiescence in culture.
Janice M. Burke,Russell Ross +1 more
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TLDR
In this article, the authors examined the ability of monkey arterial smooth muscle cells (SMC) to synthesize collagen in each of these conditions in culture and found that they synthesize the same amount of collagen/cell in 5% whole blood serum (MBS) during the early phase of rapid proliferation as during slow growth in later phases in culture.About:
This article is published in Experimental Cell Research.The article was published on 1977-07-01. It has received 100 citations till now. The article focuses on the topics: Blood serum & Hydroxyproline.read more
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Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny
Hugo Castro-Malaspina,Hugo Castro-Malaspina,Hugo Castro-Malaspina,Gene Resnick,Gene Resnick,Gene Resnick,Neena Kapoor,Neena Kapoor,Neena Kapoor,Paul A. Meyers,Paul A. Meyers,Paul A. Meyers,Dominick R. Chiarieri,Dominick R. Chiarieri,Dominick R. Chiarieri,Susan Mckenzie,Susan Mckenzie,Susan Mckenzie,Hal E. Broxmeyer,Hal E. Broxmeyer,Hal E. Broxmeyer,Malcolm A.S. Moore,Malcolm A.S. Moore,Malcolm A.S. Moore +23 more
TL;DR: Analysis of CFU-F proliferative status by the thymidine suicide technique indicated that this cell was noncycling in individuals with undisturbed bone marrow function and data support the conclusion that the colonies described in this study are of fibroblastic nature.
Journal ArticleDOI
Replication of smooth muscle cells in vascular disease.
TL;DR: This review attempts to consider the current state of knowledge of the mechanisms controlling smooth muscle proliferation in these two diseases, to put that knowledge into the context of what is known about smooth muscle biology, and to offer two hypotheses on the possible roles of smooth muscle developmental biology in manifestations of atherosclerosis and hypertension in adult humans.
Journal ArticleDOI
The platelet-derived growth factor
Russell Ross,Arthur M. Vogel +1 more
TL;DR: It is likely that PDGF is released from platelets at sites of vascular damage and that it contributes toward the cell proliferation and connective tissue formation seen in healing wounds and in arteriosclerotic lesions.
Journal ArticleDOI
Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.
TL;DR: Locally produced cytokines and growth factors may modify matrix accumulation during atherogenesis by stimulating or suppressing expression of interstitial collagen mRNA and protein by VSMCs.
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Developmentally regulated production of platelet-derived growth factor-like molecules
TL;DR: Production of PDGF-c appears to be developmentally regulated and may be a factor in the more rapid proliferation of aortic smooth muscle cells and synthesis of connective tissue components which occurs during growth of the aorta in vivo.
References
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Journal ArticleDOI
The pathogenesis of atherosclerosis (first of two parts).
Russell Ross,John A. Glomset +1 more
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The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.
TL;DR: Investigations of the morphology of smooth muscle derived from the inner media and intima of immature guinea pig aorta and radioautographic observations of the ability of aortic smooth muscle to synthesize and secrete extracellular proteins demonstrate that this cell is a connective tissue synthetic cell.
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Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis.
Russell Ross,John A. Glomset +1 more
Journal ArticleDOI
The pathogenesis of atherosclerosis (second of two parts).
Russell Ross,John A. Glomset +1 more
Journal ArticleDOI
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.
TL;DR: It is concluded that homocystine-induced endothelial cell injury resulted in arteriosclerosis through platelet-mediated intimal proliferation of smooth muscle cells that can be prevented by drug-induced platelet dysfunction.